Experience-dependent plasticity modulates ongoing activity in the antennal lobe and enhances odor representations.

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  • Additional Information
    • Source:
      Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
    • Publication Information:
      Original Publication: [Cambridge, MA] : Cell Press, c 2012-
    • Subject Terms:
      Neuronal Plasticity* ; Smell*; Arthropod Antennae/*physiology ; Drosophila melanogaster/*physiology ; Interneurons/*physiology ; Odorants/*analysis ; Olfactory Bulb/*physiology; Animals ; Arthropod Antennae/drug effects ; Calcium/metabolism ; Drosophila melanogaster/drug effects ; Female ; Interneurons/drug effects ; Olfactory Bulb/drug effects ; Olfactory Pathways
    • Abstract:
      Ongoing neural activity has been observed across several brain regions and is thought to reflect the internal state of the brain. Yet, it is important to understand how ongoing neural activity interacts with sensory experience and shapes sensory representations. Here, we show that the projection neurons of the fruit fly antennal lobe exhibit spatiotemporally organized ongoing activity. After repeated exposure to odors, we observe a gradual and cumulative decrease in the amplitude and number of calcium events occurring in the absence of odor stimulation, as well as a reorganization of correlations between olfactory glomeruli. Accompanying these plastic changes, we find that repeated odor experience decreases trial-to-trial variability and enhances the specificity of odor representations. Our results reveal an odor-experience-dependent modulation of ongoing and sensory-evoked activity at peripheral levels of the fruit fly olfactory system.
      Competing Interests: Declaration of interests The authors declare no competing interests.
      (Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.)
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    • Contributed Indexing:
      Keywords: Drosophila melanogaster; antennal lobe; calcium imaging; experience-dependent plasticity; fruit fly; olfaction; olfactory system; ongoing activity; plasticity
    • Accession Number:
      SY7Q814VUP (Calcium)
    • Publication Date:
      Date Created: 20211229 Date Completed: 20220215 Latest Revision: 20220215
    • Publication Date:
      20231215
    • Accession Number:
      PMC8739562
    • Accession Number:
      10.1016/j.celrep.2021.110165
    • Accession Number:
      34965425