Alterations in CNS Functions and DNA Methylation in Rats after 24 h Exposure to Peat Smoke.

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  • Additional Information
    • Source:
      Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101639637 Publication Model: Electronic Cited Medium: Internet ISSN: 2305-6304 (Electronic) Linking ISSN: 23056304 NLM ISO Abbreviation: Toxics Subsets: PubMed not MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI AG, [2013]-
    • Abstract:
      The use of a developed experimental model of a natural fire made it possible to assess the consequences of 24 h exposure to peat combustion products in albino rats. Peat smoke exposure leads to behavioral disturbances in rats, characterized by an increase in locomotor activity and an increased level of anxiety. Indicators of brain bioelectrical activity of the exposed animals supported the state of anxiety and psychoemotional stress. Epigenetic changes in the blood cells of exposed animals were revealed under 24 h exposure to peat smoke, characterized by a decrease in the level of global DNA methylation.
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    • Grant Information:
      075-15-2020-787 Ministry of Science and Higher Education
    • Contributed Indexing:
      Keywords: DNA fragmentation and methylation; EEG; behavior; peat smoke; rats
    • Publication Date:
      Date Created: 20211223 Latest Revision: 20211228
    • Publication Date:
      20221213
    • Accession Number:
      PMC8709141
    • Accession Number:
      10.3390/toxics9120342
    • Accession Number:
      34941776