Endophilin-B regulates autophagy during synapse development and neurodegeneration.

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  • Additional Information
    • Source:
      Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE
    • Publication Information:
      Publication: San Diego, CA : Academic Press
      Original Publication: Oxford : Blackwell Science, c1994-
    • Subject Terms:
      Acyltransferases/*metabolism ; Autophagy/*genetics ; Dopaminergic Neurons/*metabolism ; Drosophila Proteins/*metabolism ; Nerve Degeneration/*metabolism ; Synapses/*metabolism; Acyltransferases/genetics ; Animals ; Animals, Genetically Modified ; Dopaminergic Neurons/pathology ; Drosophila ; Drosophila Proteins/genetics ; Nerve Degeneration/genetics ; Nerve Degeneration/pathology ; Synapses/genetics
    • Abstract:
      Synapses are critical for neuronal communication and brain function. To maintain neuronal homeostasis, synapses rely on autophagy. Autophagic alterations cause neurodegeneration and synaptic dysfunction is a feature in neurodegenerative diseases. In Parkinson's disease (PD), where the loss of synapses precedes dopaminergic neuron loss, various PD-causative proteins are involved in the regulation of autophagy. So far only a few factors regulating autophagy at the synapse have been identified and the molecular mechanisms underlying autophagy at the synapse is only partially understood. Here, we describe Endophilin-B (EndoB) as a novel player in the regulation of synaptic autophagy in health and disease. We demonstrate that EndoB is required for autophagosome biogenesis at the synapse, whereas the loss of EndoB blocks the autophagy induction promoted by the PD mutation LRRK2 G2019S . We show that EndoB is required to prevent neuronal loss. Moreover, loss of EndoB in the Drosophila visual system leads to an increase in synaptic contacts between photoreceptor terminals and their post-synaptic synapses. These data confirm the role of autophagy in synaptic contact formation and neuronal survival.
      (Copyright © 2021. Published by Elsevier Inc.)
    • Contributed Indexing:
      Keywords: Autophagy; Drosophila; Neurodegeneration; Parkinson's disease; Synapse development
    • Accession Number:
      0 (Drosophila Proteins)
      EC 2.3.- (Acyltransferases)
      EC 2.3.1.52 (endophilin B, Drosophila)
    • Publication Date:
      Date Created: 20211221 Date Completed: 20220323 Latest Revision: 20220323
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.nbd.2021.105595
    • Accession Number:
      34933093