Cerebral dominance in an unusual case of Landau-Kleffner syndrome.

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  • Additional Information
    • Source:
      Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 101526291 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-790X (Electronic) Linking ISSN: 1757790X NLM ISO Abbreviation: BMJ Case Rep Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BMJ Pub. Group
    • Subject Terms:
      Landau-Kleffner Syndrome*/diagnosis ; Status Epilepticus*/diagnosis ; Status Epilepticus*/drug therapy; Child ; Dominance, Cerebral ; Electroencephalography ; Humans ; Male ; Seizures/etiology ; Sleep
    • Abstract:
      Landau-Kleffner syndrome (LKS) is described by the International Classification of Epileptic Syndromes since 1985 as a constellation of clinical and electrographic signs, including acquired aphasia, regression of language milestones and seizures, along with sleep-activated paroxysms on electroencephalogram which can progress to electrographic status epilepticus of sleep. In this case, a 7-year-old boy presented with an atypical history of new-onset aphasia and regression of language milestones with rare seizures. However, there was an electrographic mismatch in the form of right-sided epileptiform activity and continuous spike and wave of sleep pattern. Detailed speech analysis and perusal of the history revealed a possibly ambidextrous child with right hemispheric language dominance, and he was diagnosed with LKS and treated. This report illustrates the many pitfalls in the diagnosis and treatment of this rare epileptic syndrome.
      Competing Interests: Competing interests: None declared.
      (© BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.)
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    • Contributed Indexing:
      Keywords: clinical neurophysiology; epilepsy and seizures; neurology
    • Publication Date:
      Date Created: 20211210 Date Completed: 20211213 Latest Revision: 20231212
    • Publication Date:
      20240829
    • Accession Number:
      PMC8663068
    • Accession Number:
      10.1136/bcr-2021-246696
    • Accession Number:
      34887295