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The Curious Case of the HepG2 Cell Line: 40 Years of Expertise.
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- Author(s): Arzumanian VA;Arzumanian VA; Kiseleva OI; Kiseleva OI; Poverennaya EV; Poverennaya EV
- Source:
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 04; Vol. 22 (23). Date of Electronic Publication: 2021 Dec 04.- Publication Type:
Journal Article; Review- Language:
English - Source:
- Additional Information
- Source: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
- Publication Information: Original Publication: Basel, Switzerland : MDPI, [2000-
- Subject Terms:
- Abstract: Liver cancer is the third leading cause of cancer death worldwide. Representing such a dramatic impact on our lives, liver cancer is a significant public health concern. Sustainable and reliable methods for preventing and treating liver cancer require fundamental research on its molecular mechanisms. Cell lines are treated as in vitro equivalents of tumor tissues, making them a must-have for basic research on the nature of cancer. According to recent discoveries, certified cell lines retain most genetic properties of the original tumor and mimic its microenvironment. On the other hand, modern technologies allowing the deepest level of detail in omics landscapes have shown significant differences even between samples of the same cell line due to cross- and mycoplasma infection. This and other observations suggest that, in some cases, cell cultures are not suitable as cancer models, with limited predictive value for the effectiveness of new treatments. HepG2 is a popular hepatic cell line. It is used in a wide range of studies, from the oncogenesis to the cytotoxicity of substances on the liver. In this regard, we set out to collect up-to-date information on the HepG2 cell line to assess whether the level of heterogeneity of the cell line allows in vitro biomedical studies as a model with guaranteed production and quality.
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Mutat Res Genet Toxicol Environ Mutagen. 2018 Jan;825:51-58. (PMID: 29307375) - Grant Information: 20-14-00328 Russian Science Foundation
- Contributed Indexing: Keywords: HepG2 cell line; hepatoblastoma; hepatocellular carcinoma; hepatocytes; mutations
- Accession Number: 0 (Proteins)
- Publication Date: Date Created: 20211210 Date Completed: 20220107 Latest Revision: 20240928
- Publication Date: 20240928
- Accession Number: PMC8658661
- Accession Number: 10.3390/ijms222313135
- Accession Number: 34884942
- Source:
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