A mutant of the motor protein kinesin that moves in both directions on microtubules.

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  • Author(s): Endow, Sharyn A.; Higuchi, Hideo
  • Source:
    Nature. 8/24/2000, Vol. 406 Issue 6798, p913. 4p. 1 Black and White Photograph, 1 Diagram, 2 Graphs.
  • Additional Information
    • Subject Terms:
      KINESIN; MICROTUBULES; GENETIC mutation; AMINO acids
    • Abstract:
      Presents a study which shows that a single amino-acid change in the neck of the kinesin-related Ncd motor causes it to reverse directions and move with wild-type velocities towards the plus or minus end. Usual direction of Ncd, which is toward the minus end; Conclusion that the directional bias of the working stroke is dependent on neck/motor core interactions, the absence of which removes directional constraints.