HLA-DR 3 is associated with a more slowly progressive form of type 1 (insulin-dependent) diabetes.

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  • Additional Information
    • Source:
      Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print Cited Medium: Print ISSN: 0012-186X (Print) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
    • Publication Information:
      Original Publication: Berlin Springer Verlag
    • Subject Terms:
      Diabetes Mellitus, Type 1/*genetics ; Histocompatibility Antigens Class II/*analysis; Adolescent ; Adult ; Child ; Child, Preschool ; Europe ; Female ; Genetic Markers ; Genotype ; HLA-DR3 Antigen ; HLA-DR4 Antigen ; Humans ; Infant ; Male ; Phenotype ; Sex Factors ; United States
    • Abstract:
      The presence of HLA-DR 3 was analysed in 745 patients with Type 1 (insulin-dependent) diabetes with age at diagnosis between 1-19 years. HLA-DR 3 and/or 4 was found in 678/745 (91%) of the patients. Presence of DR2 with neither DR 3 nor 4 was demonstrated in 15 patients. Patients with HLA-DR 3 without DR 4 presented with Type 1 diabetes more evenly over the year; they also presented without incidence peaks at 7 years or 10-11 years, as seen especially in DR 3/4 patients. The DR 3 patients more often had mild disease with less ketonuria at diagnosis, less often ketoacidotic symptoms and more often a subsequent partial remission. The apparently more severe disease among diabetic girls may, at least to some extent, be explained by their higher prevalence of HLA-DR 4. The differences found were similar in North America and Europe. The results suggest that Type 1 diabetes is a genetically heterogeneous disease and that HLA-typing may be a useful marker of this heterogeneity.
    • References:
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    • Accession Number:
      0 (Genetic Markers)
      0 (HLA-DR3 Antigen)
      0 (HLA-DR4 Antigen)
      0 (Histocompatibility Antigens Class II)
    • Publication Date:
      Date Created: 19860401 Date Completed: 19860724 Latest Revision: 20190816
    • Publication Date:
      20240829
    • Accession Number:
      10.1007/BF00454876
    • Accession Number:
      3486790