Fructooligosaccharide ameliorates high-fat induced intrauterine inflammation and improves lipid profile in the hamster offspring.

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  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: United States NLM ID: 9010081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4847 (Electronic) Linking ISSN: 09552863 NLM ISO Abbreviation: J Nutr Biochem Subsets: MEDLINE
    • Publication Information:
      Publication: <1996->: New York, NY : Elsevier Science
      Original Publication: Stoneham, MA, USA : Butterworths, c1990-
    • Subject Terms:
      Maternal Nutritional Physiological Phenomena* ; Oligosaccharides* ; Prebiotics*; Diet, High-Fat/*adverse effects ; Inflammation/*prevention & control ; Lipids/*blood; Adiposity ; Animals ; Blood Glucose/analysis ; Body Weight ; Chorioallantoic Membrane/immunology ; Cytokines/metabolism ; Female ; Lipid Metabolism ; Lipoproteins, HDL/blood ; Mesocricetus ; Neutrophil Infiltration ; Placenta/immunology ; Pregnancy ; Triglycerides/blood
    • Abstract:
      Maternal high-fat diet (HFD) often results in intrauterine and feto-placental inflammation, and increases the risks of fetal programming of metabolic diseases. Intake of prebiotic is reported beneficial. However, its effects on HFD during pregnancy and lactation is not known. We evaluated the maternal intake of fructooligosaccharide (FOS) and its impact on placental inflammation, offspring's adiposity, glucose, and lipid metabolism in their later life. Female Golden Syrian hamsters were fed with a control diet (CD, 26.4 % energy from fat) or HFD (60.7% energy from fat) in the presence or absence of FOS from preconception until lactation. All pups were switched over to CD after lactation and continued until the end. Placental inflammation was upregulated in HFD-fed dam, as measured by a high concentration of hsCRP in the serum and amniotic fluid. Neutrophil infiltration was significantly increased in the decidua through the chorionic layer of the placenta. The expression of pro-inflammatory cytokines such as COX2, NFκβ, IL-8, TGFβ mRNA was increased in the chorioamniotic membrane (P <.05). The HFD/CD hamsters had more adiposity, higher triglyceride, and low HDL at 12 months of age compared to CD/CD (P <.05). However, HFD+FOS/CD-fed hamsters prevented adverse effects such as placental inflammation, neutrophil infiltration, glucose, and lipid profiles in the offspring (P <.05). Anti-inflammatory and lipid-lowering effects of FOS may reduce placental inflammation by lowering neutrophil infiltration and decreasing the production of pro-inflammatory cytokines. Intake of FOS during pregnancy may be beneficial in maintaining lipid metabolism and preventing excess adiposity for mother and their offspring.
      (Copyright © 2021. Published by Elsevier Inc.)
    • Contributed Indexing:
      Keywords: Fructooligosaccharide; High-fat diet; Intrauterine inflammation; Neutrophil infiltration; Prebiotic; Pregnancy
    • Accession Number:
      0 (Blood Glucose)
      0 (Cytokines)
      0 (Lipids)
      0 (Lipoproteins, HDL)
      0 (Oligosaccharides)
      0 (Prebiotics)
      0 (Triglycerides)
      0 (fructooligosaccharide)
    • Publication Date:
      Date Created: 20211129 Date Completed: 20220307 Latest Revision: 20220307
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/j.jnutbio.2021.108925
    • Accession Number:
      34843933