[Overexpression of ephrin-A receptor 2 (EphA2) in invasive breast cancer tissues and its negative correlation with pyroptosis].

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  • Additional Information
    • Source:
      Publisher: Xi bao yu fen zi mian yi xue za zhi bian ji bu Country of Publication: China NLM ID: 101139110 Publication Model: Print Cited Medium: Print ISSN: 1007-8738 (Print) Linking ISSN: 10078738 NLM ISO Abbreviation: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi Subsets: MEDLINE
    • Publication Information:
      Original Publication: Xiʹan : Xi bao yu fen zi mian yi xue za zhi bian ji bu
    • Subject Terms:
      Breast Neoplasms*/genetics ; Pyroptosis*; Receptor, EphA2/*genetics; Caspase 1/genetics ; Ephrins ; Female ; Humans ; Inflammasomes ; Interleukin-1beta/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics
    • Abstract:
      Objective To investigate how ephrin-A receptor 2 (EphA2) involves in pyroptosis in invasive breast cancer tissues. Methods The protein expression levels of EphA2, NLR family pyrin domain containing 3 (NLRP3), caspase-1, interleukin-1β (IL-1β), and intercellular adhesion molecule-1 (ICAM-1) in cancer tissues, paracancerous tissues, and normal breast tissues of breast cancer patients were detected by Western blot; the expression of EPHA2 in cancer tissues and paracancerous tissues of 45 patients with breast cancer was detected by immunofluorescence assay; and the correlation between protein expression of EphA2 and NLRP3, caspase-1, and IL-1β in patients' cancer tissues was analyzed by Pearson correlation coefficient. Results The protein expression levels of NLRP3, caspase-1, IL-1β, and ICAM-1 were significantly decreased and the protein expression of EphA2 was significantly increased in cancer tissues compared with those in normal breast tissues and paracancerous tissues. EphA2 level was negatively correlated with the levels of NLRP3, caspase-1 and IL-1β. Conclusion EphA2 is overexpressed in breast cancer tissues and negatively correlated with pyroptosis.
    • Accession Number:
      0 (EPHA2 protein, human)
      0 (Ephrins)
      0 (Inflammasomes)
      0 (Interleukin-1beta)
      0 (NLR Family, Pyrin Domain-Containing 3 Protein)
      EC 2.7.10.1 (Receptor, EphA2)
      EC 3.4.22.36 (Caspase 1)
    • Publication Date:
      Date Created: 20211123 Date Completed: 20211124 Latest Revision: 20220531
    • Publication Date:
      20221213
    • Accession Number:
      34809737