Respiratory symptoms (COPD Assessment Test and modified Medical Research Council dyspnea scores) and GOLD-ABCD COPD classification: the LASSYC study.

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  • Additional Information
    • Source:
      Publisher: Sociedade Brasileira de Pneumologia e Tisilogia Country of Publication: Brazil NLM ID: 101222274 Publication Model: eCollection Cited Medium: Internet ISSN: 1806-3756 (Electronic) Linking ISSN: 18063713 NLM ISO Abbreviation: J Bras Pneumol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Brasilia, DF, Brasil : Sociedade Brasileira de Pneumologia e Tisilogia, [2004]-
    • Subject Terms:
      Biomedical Research* ; Pulmonary Disease, Chronic Obstructive*/diagnosis; Cross-Sectional Studies ; Dyspnea/diagnosis ; Dyspnea/etiology ; Humans ; Male ; Severity of Illness Index ; Surveys and Questionnaires
    • Abstract:
      Objective: To assess the frequency and severity of 24-hour respiratory symptoms according to COPD GOLD-ABCD classification (2017-version), the distribution of the patients with COPD into GOLD categories using mMRC (≥2) or CAT (≥10) scores, and agreement between these cut-off points.
      Methods: In this cross-sectional study (LASSYC study), 24-hour day respiratory symptoms were assessed by the Evaluating Respiratory Symptoms in COPD (E-RS) questionnaire, Nighttime Symptoms of COPD Instrument (NiSCI), Early Morning Symptoms of COPD Instrument (EMSCI), CAT and mMRC scores.
      Results: Among the 734 patients with COPD, 61% were male, age 69.6±8.7 years, FEV1% post-BD 49.1±17.5%, mMRC 1.8±1.0 and CAT 15.3±.8.1. By mMRC 33.7% were group-A, 29.2% group-B, 10.2% group-C and 26.9% group-D. By CAT 22.3% were group-A, 41% group-B, 4.8% group-C and 31.9% group-D. Using the mMRC the severity of E-RS, NiSCI and EMSCI scores increased from group A to D. Using the CAT, the groups B and D had the higher scores. Agreement between mMRC and CAT was 89.5% (Kappa statistics=75.7%). For mMRC score of 2, CAT score of ≥11 showed the maximum Youden's index (1.34). For mMRC score of 1, CAT score of ≥9 and ≥10 showed the maximum Youden's index (1.48).
      Conclusion: GOLD COPD classification by CAT seems to better discriminate 24-hour symptoms. Results do not support the equivalent use of CAT≥10 and mMRC≥2 for assessing symptoms.
    • Comments:
      Comment in: J Bras Pneumol. 2021 Dec 01;47(5):e20210389. doi: 10.36416/1806-3756/e20210389. (PMID: 34878055)
    • Publication Date:
      Date Created: 20211117 Date Completed: 20220120 Latest Revision: 20220120
    • Publication Date:
      20250114
    • Accession Number:
      10.36416/1806-3756/e20210156
    • Accession Number:
      34787288