The ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila.

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  • Author(s): Sang Q;Sang Q; Wang G; Wang G; Morton DB; Morton DB; Wu H; Wu H; Xie B; Xie B
  • Source:
    PLoS genetics [PLoS Genet] 2021 Nov 08; Vol. 17 (11), pp. e1009894. Date of Electronic Publication: 2021 Nov 08 (Print Publication: 2021).
  • Publication Type:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science, c2005-
    • Subject Terms:
      Drosophila Proteins/*metabolism ; Drosophila melanogaster/*metabolism ; Intracellular Signaling Peptides and Proteins/*metabolism ; Protein Serine-Threonine Kinases/*metabolism ; Tight Junction Proteins/*metabolism ; Zonula Occludens-1 Protein/*metabolism; Animals ; Drosophila Proteins/genetics ; Heterozygote ; Signal Transduction ; Tight Junction Proteins/genetics ; Zonula Occludens-1 Protein/genetics
    • Abstract:
      The generation of a diversity of photoreceptor (PR) subtypes with different spectral sensitivities is essential for color vision in animals. In the Drosophila eye, the Hippo pathway has been implicated in blue- and green-sensitive PR subtype fate specification. Specifically, Hippo pathway activation promotes green-sensitive PR fate at the expense of blue-sensitive PRs. Here, using a sensitized triple heterozygote-based genetic screening approach, we report the identification of the single Drosophila zonula occludens-1 (ZO-1) protein Polychaetoid (Pyd) as a new regulator of the Hippo pathway during the blue- and green-sensitive PR subtype binary fate choice. We demonstrate that Pyd acts upstream of the core components and the upstream regulator Pez in the Hippo pathway. Furthermore, We found that Pyd represses the activity of Su(dx), a E3 ligase that negatively regulates Pez and can physically interact with Pyd, during PR subtype fate specification. Together, our results identify a new mechanism underlying the Hippo signaling pathway in post-mitotic neuronal fate specification.
      Competing Interests: The authors have declared that no competing interests exist.
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    • Grant Information:
      R01 DE017954 United States DE NIDCR NIH HHS; R01 DE022350 United States DE NIDCR NIH HHS; R01 DE028329 United States DE NIDCR NIH HHS
    • Accession Number:
      0 (Drosophila Proteins)
      0 (Intracellular Signaling Peptides and Proteins)
      0 (Tight Junction Proteins)
      0 (Zonula Occludens-1 Protein)
      0 (pyd protein, Drosophila)
      EC 2.7.11.1 (Protein Serine-Threonine Kinases)
      EC 2.7.11.1 (hpo protein, Drosophila)
    • Publication Date:
      Date Created: 20211108 Date Completed: 20220106 Latest Revision: 20220106
    • Publication Date:
      20221213
    • Accession Number:
      PMC8610254
    • Accession Number:
      10.1371/journal.pgen.1009894
    • Accession Number:
      34748546