[Atherosclerosis prevention: new therapeutic strategies on the horizon].

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  • Additional Information
    • Transliterated Title:
      Prevenzione dell’aterosclerosi: nuove strategie terapeutiche all’orizzonte.
    • Source:
      Publisher: Il Pensiero Scientifico Editore Country of Publication: Italy NLM ID: 101263411 Publication Model: Print Cited Medium: Internet ISSN: 1972-6481 (Electronic) Linking ISSN: 18276806 NLM ISO Abbreviation: G Ital Cardiol (Rome) Subsets: MEDLINE
    • Publication Information:
      Publication: Roma : Il Pensiero Scientifico Editore
      Original Publication: Roma : CEPI-AIM Group, [2006]-
    • Subject Terms:
      Atherosclerosis*/drug therapy ; Atherosclerosis*/prevention & control; Cholesterol, LDL ; Humans ; Lipoprotein(a) ; Oligonucleotides ; Triglycerides
    • Abstract:
      In order to comprehensively address atherosclerotic risk, the need to achieve and maintain very low LDL-cholesterol levels and manage other atherogenic factors has led to the development of new therapeutic options. This review reports the main agents in an advanced status of development that have LDL-cholesterol, triglycerides, lipoprotein(a), inflammation, and body weight as therapeutic targets. We discuss the mechanism of action, biological effects, and safety profile of these new drugs (bempedoic acid, lomitapide, inclisiran, evinacumab, vupanorsen, mipomersen, eicosapent ethyl, volanesorsen, pemafibrate, AKCEA-APO(a)-LRx, colchicine, semaglutide). Lastly, we briefly report therapeutic interventions based on biotechnological methods that could be implemented in the near future.
    • Accession Number:
      0 (AKCEA-APO(a)-LRx)
      0 (Cholesterol, LDL)
      0 (Lipoprotein(a))
      0 (Oligonucleotides)
      0 (Triglycerides)
    • Publication Date:
      Date Created: 20211028 Date Completed: 20211101 Latest Revision: 20211101
    • Publication Date:
      20221213
    • Accession Number:
      10.1714/3689.36751
    • Accession Number:
      34709232