Soil-transmitted helminth infections after mass drug administration for lymphatic filariasis in rural southern India.

Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9610576 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-3156 (Electronic) Linking ISSN: 13602276 NLM ISO Abbreviation: Trop Med Int Health Subsets: MEDLINE

Publication: Oxford : Blackwell Scientific Publications
Original Publication: Oxford, UK : Blackwell Science Ltd, c1996-

Soil Microbiology*; Albendazole/*therapeutic use ; Anthelmintics/*therapeutic use ; Elephantiasis, Filarial/*epidemiology; Adolescent ; Adult ; Aged ; Albendazole/administration & dosage ; Animals ; Anthelmintics/administration & dosage ; Child ; Child, Preschool ; Cross-Sectional Studies ; Elephantiasis, Filarial/drug therapy ; Elephantiasis, Filarial/parasitology ; Feces/parasitology ; Female ; Humans ; India/epidemiology ; Infant ; Male ; Middle Aged ; Prevalence ; Rural Health Services ; Surveys and Questionnaires ; Young Adult

Objectives: Targeted deworming is the current strategy for control of morbidity associated with soil-transmitted helminths (STH) among at-risk populations: preschool-aged children, school-aged children and women of childbearing age. We report the prevalence and intensity of STH in a district after lymphatic filariasis (LF) mass drug administration (MDA) in southern India where albendazole was co-administered from 2001.
Methods: Children aged 2 to 15 years and adults (defined as ≥15 years) in a rural administrative block of Tamil Nadu were recruited using a probability proportional to size method. Stool samples were screened and eggs per gram (EPG) determined by Kato-Katz method. Multilevel logistic regression (MLR) and multilevel negative binomial regression (MNBR) analyses were used to identify factors associated with infection and intensity, respectively.
Results: Of 862 participants who provided samples, 60 (7.0%; 95% confidence interval (CI): 5.3-8.7) were positive for STH with a predominance of hookworm infections (n = 57, 6.6%; 95% CI: 5.0-8.3). Increasing age (odds ratio (OR): 1.09; 95% CI: 1.04-1.15) and regular usage of the toilet (OR: 0.32; 95% CI: 0.12-0.88) were independently associated with hookworm infection and age was significantly associated with increasing intensity of hookworm infection (infection intensity ratio (IIR): 1.28; 95% CI: 1.19-1.37). A brief review of STH prevalence in endemic settings before and after the stoppage of LF MDA indicated that, in most settings, a substantial reduction in STH prevalence is seen.
Conclusion: Community-wide MDA in all age groups in these post-LF MDA districts with low prevalence and light intensity infections could result in transmission interruption of STH.
(© 2021 John Wiley & Sons Ltd.)

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Keywords: Kato-Katz; hookworm; intensity; mass drug administration; prevalence; soil-transmitted helminths

0 (Anthelmintics)
F4216019LN (Albendazole)

Date Created: 20211027 Date Completed: 20220224 Latest Revision: 20220224

20231215

10.1111/tmi.13697

34704320