A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage.

Publisher: Wiley Periodicals, Inc on behalf of American Neurological Association Country of Publication: United States NLM ID: 101623278 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2328-9503 (Electronic) Linking ISSN: 23289503 NLM ISO Abbreviation: Ann Clin Transl Neurol Subsets: MEDLINE

Original Publication: [Hoboken, NJ] : Wiley Periodicals, Inc on behalf of American Neurological Association, [2014]-

Hematologic Agents* ; Neurological Rehabilitation* ; Neurosurgical Procedures* ; Secondary Prevention* ; Stem Cell Transplantation*; Cerebral Hemorrhage/*therapy; Cerebral Hemorrhage/drug therapy ; Cerebral Hemorrhage/surgery ; Humans

Intracerebral hemorrhage (ICH) remains a common and debilitating form of stroke. This neurological emergency must be diagnosed and treated rapidly yet effectively. In this article, we review the medical, surgical, repair, and regenerative treatment options for managing ICH. Topics of focus include the management of blood pressure, intracranial pressure, coagulopathy, and intraventricular hemorrhage, as well as the role of surgery, regeneration, rehabilitation, and secondary prevention. Results of various phase II and III trials are incorporated. In summary, ICH patients should undergo rapid evaluation with neuroimaging, and early interventions should include systolic blood pressure control in the range of 140 mmHg, correction of coagulopathy if indicated, and assessment for surgical intervention. ICH patients should be managed in dedicated neurosurgical intensive care or stroke units where continuous monitoring of neurological status and evaluation for neurological deterioration is rapidly possible. Extravasation of hematoma may be helpful in patients with intraventricular extension of ICH. The goal of care is to reduce mortality and enable multimodal rehabilitative therapy.
(© 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.)

Crit Pathw Cardiol. 2007 Mar;6(1):18-23. (PMID: 17667882)
Neurology. 2008 Apr 15;70(16):1322-8. (PMID: 18256366)
Neuron. 2010 Apr 29;66(2):198-204. (PMID: 20434997)
Cochrane Database Syst Rev. 2018 May 23;5:CD007286. (PMID: 29791030)
Stroke. 2012 Jan;43(1):67-71. (PMID: 21980211)
Lancet. 2018 May 26;391(10135):2107-2115. (PMID: 29778325)
Stroke. 2003 Jul;34(7):1710-6. (PMID: 12805495)
Lancet Neurol. 2019 May;18(5):428-438. (PMID: 30898550)
Lancet. 2013 Aug 3;382(9890):397-408. (PMID: 23726393)
Neurology. 2014 Jun 17;82(24):2180-6. (PMID: 24838789)
Stroke Res Treat. 2014;2014:234095. (PMID: 25126443)
Disabil Rehabil. 2016;38(7):637-43. (PMID: 26079636)
Stroke. 2012 Nov;43(11):2923-30. (PMID: 22989500)
Neurol Med Chir (Tokyo). 2017 Nov 15;57(11):563-574. (PMID: 28819090)
Neurocrit Care. 2013 Aug;19(1):19-24. (PMID: 23138543)
J Stroke Cerebrovasc Dis. 2020 Mar;29(3):104583. (PMID: 31862153)
Neurol Res Pract. 2019 May 10;1:12. (PMID: 33324878)
N Engl J Med. 2013 Jun 20;368(25):2355-65. (PMID: 23713578)
Stroke. 2017 Mar;48(3):596-603. (PMID: 28228576)
Front Neurol. 2017 Mar 15;8:80. (PMID: 28360881)
Lancet. 2017 Feb 11;389(10069):603-611. (PMID: 28081952)
J Neurosurg. 2012 Oct;117(4):761-6. (PMID: 22880718)
Lancet Neurol. 2016 Nov;15(12):1228-1237. (PMID: 27751554)
Front Neurol. 2018 Dec 11;9:1091. (PMID: 30619050)
Neurology. 2003 Nov 25;61(10):1351-6. (PMID: 14638954)
Int J Stroke. 2019 Dec;14(9):987-995. (PMID: 30681042)
JAMA. 1998 Dec 9;280(22):1930-5. (PMID: 9851479)
J Stroke. 2017 Jan;19(1):28-39. (PMID: 28178413)
Neurocrit Care. 2011 Apr;14(2):291-317. (PMID: 21080105)
Neurocrit Care. 2016 Feb;24(1):47-60. (PMID: 26646118)
Cerebrovasc Dis. 2005;19(2):96-101. (PMID: 15608433)
Lancet Neurol. 2009 Apr;8(4):355-69. (PMID: 19233729)
N Engl J Med. 2008 May 15;358(20):2127-37. (PMID: 18480205)
Neurology. 2010 Oct 12;75(15):1333-42. (PMID: 20826714)
Stroke. 2004 Jun;35(6):1364-7. (PMID: 15118169)
Stroke. 2015 Jul;46(7):2032-60. (PMID: 26022637)
Neuroepidemiology. 2020;54(2):171-179. (PMID: 32079017)
J Neurol Sci. 2019 Mar 15;398:39-44. (PMID: 30682519)
Acta Neurochir Suppl. 2008;105:43-6. (PMID: 19066080)
Surg Neurol. 2005 Aug;64(2):160-4; discussion 164. (PMID: 16051011)
J Neurol Neurosurg Psychiatry. 2007 Jul;78(7):729-31. (PMID: 17135457)
Brain Pathol. 2018 Nov;28(6):844-859. (PMID: 30062722)
Neurologia. 2013 May;28(4):236-49. (PMID: 21570742)
Lancet. 2015 Nov 21;386(10008):2059-2068. (PMID: 26414968)
J Clin Neurosci. 2002 Jan;9(1):4-8. (PMID: 11749009)
Stroke Vasc Neurol. 2017 Feb 24;2(1):21-29. (PMID: 28959487)
J Am Heart Assoc. 2015 May 06;4(5):. (PMID: 25950185)
Int J Stroke. 2009 Feb;4(1):11-6. (PMID: 19236490)
Int J Stroke. 2014 Aug;9(6):741-6. (PMID: 24025067)
Neurology. 2006 Apr 25;66(8):1182-6. (PMID: 16636234)
Clin Neurol Neurosurg. 2013 Jan;115(1):72-6. (PMID: 22657095)
Neurology. 2010 Aug 24;75(8):693-8. (PMID: 20733144)
J Neurol Neurosurg Psychiatry. 2007 Aug;78(8):836-40. (PMID: 17220294)
Neurology. 2002 Jul 23;59(2):205-9. (PMID: 12136058)
Stroke. 2018 Nov;49(11):2612-2620. (PMID: 30355183)
Neurocrit Care. 2012 Feb;16(1):63-71. (PMID: 21847702)
Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1590-5. (PMID: 19164589)
Neurocrit Care. 2009;11(1):28-33. (PMID: 19238588)
J Stroke Cerebrovasc Dis. 2016 Sep;25(9):2159-66. (PMID: 27289186)
Crit Care. 2008;12(6):237. (PMID: 19108704)
Neurocrit Care. 2013 Feb;18(1):59-63. (PMID: 21761271)
Stroke. 2004 Jun;35(6):1415-20. (PMID: 15073385)
Brain Inj. 2010;24(5):730-5. (PMID: 20334471)
Lancet. 2005 Jan 29-Feb 4;365(9457):387-97. (PMID: 15680453)
Sci Rep. 2016 Jul 07;6:29246. (PMID: 27385592)
J Am Coll Cardiol. 1998 Aug;32(2):536-9. (PMID: 9708488)
J Transl Med. 2011 Mar 22;9:29. (PMID: 21418664)
Crit Care. 2015 Nov 17;19:409. (PMID: 26577436)
Semin Neurol. 2016 Jun;36(3):306-12. (PMID: 27214706)
Restor Neurol Neurosci. 2009;27(3):151-61. (PMID: 19531871)
Neurology. 2020 Jan 21;94(3):e314-e322. (PMID: 31831597)
N Engl J Med. 2009 Mar 26;360(13):1283-97. (PMID: 19318384)
Crit Care Med. 2001 Mar;29(3):635-40. (PMID: 11373434)
Lancet Neurol. 2005 Oct;4(10):662-72. (PMID: 16168935)
Ann Neurol. 2012 Feb;71(2):199-205. (PMID: 22367992)
Am J Cardiol. 2005 Dec 15;96(12):1731-3. (PMID: 16360366)
Crit Care. 2020 Feb 7;24(1):45. (PMID: 32033578)
Mediators Inflamm. 2015;2015:516740. (PMID: 25878400)
Lancet Neurol. 2014 Apr;13(4):364-73. (PMID: 24530176)
Stem Cells. 2019 Nov;37(11):1481-1491. (PMID: 31529663)
Stroke. 2010 Dec;41(12):2860-6. (PMID: 21030703)
Stem Cells Int. 2015;2015:318269. (PMID: 26240570)
Stroke. 2019 Apr;50(4):939-946. (PMID: 30869568)
Clin Neurol Neurosurg. 2017 Nov;162:12-15. (PMID: 28892716)
J Stroke. 2017 Jan;19(1):3-10. (PMID: 28178408)
Stroke. 2016 Nov;47(11):2749-2755. (PMID: 27758940)
N Engl J Med. 2001 May 10;344(19):1450-60. (PMID: 11346811)
Cerebrovasc Dis Extra. 2011 Jan-Dec;1(1):93-104. (PMID: 22566987)
Stroke. 2010 Jun;41(6):1222-8. (PMID: 20431083)
Stroke. 2011 Jun;42(6):1540-5. (PMID: 21512173)
N Engl J Med. 2016 Sep 15;375(11):1033-43. (PMID: 27276234)
QJM. 2013 Jan;106(1):11-25. (PMID: 23019591)
J Stroke Cerebrovasc Dis. 2013 Jul;22(5):661-7. (PMID: 22633254)
Lancet. 2019 Mar 9;393(10175):1021-1032. (PMID: 30739747)
J Neurol Neurosurg Psychiatry. 2009 Aug;80(8):881-7. (PMID: 19332423)

0 (Hematologic Agents)

Date Created: 20211014 Date Completed: 20220228 Latest Revision: 20240404

20240404

PMC8607450

10.1002/acn3.51443

34647437