Paeonol assists fluconazole and amphotericin B to inhibit virulence factors and pathogenicity of Candida albicans .

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  • Additional Information
    • Source:
      Publisher: Taylor & Francis Country of Publication: England NLM ID: 9200331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2454 (Electronic) Linking ISSN: 08927014 NLM ISO Abbreviation: Biofouling Subsets: MEDLINE
    • Publication Information:
      Publication: 2002- : Abingdon, Oxford : Taylor & Francis
      Original Publication: Chur ; New York : Harwood Academic Publishers, c1988-
    • Subject Terms:
      Amphotericin B*/pharmacology ; Fluconazole*/pharmacology; Acetophenones ; Antifungal Agents/pharmacology ; Candida albicans ; Microbial Sensitivity Tests ; Virulence ; Virulence Factors
    • Abstract:
      This study aimed to evaluate the mono- and dual- antifungal activities of paeonol (PAE) and fluconazole (FLZ)/amphotericin B (AmB). To this end, the effects of PAE and FLZ/AmB on cell surface hydrophobicity, hydrolase activity, morphological transition were investigated in vitro and in a Galleria mellonella infection model. The results showed a relatively high minimum inhibitory concentration (MIC) and sessile MIC (SMIC) of PAE alone. However, compared with the single drug, the combined use of PAE and FLZ/AmB had a potent synergistic potential to inhibit the virulence factors for Candida . The concomitant use of two drugs was consistently more effective than either drug alone for increasing survival rate, decreasing the fungal burden, and alleviating the pathological features of G. mellonella infected by the fungus. Taken together, these findings demonstrate the anti- Candida effects of PAE plus FLZ/AmB and their potential to increase the sensitivity of C. albicans to FLZ/AmB of PAE.
    • Contributed Indexing:
      Keywords: Candida albicans; Galleria mellonella; hypha; paeonol; sensitizer; virulence factors
    • Accession Number:
      0 (Acetophenones)
      0 (Antifungal Agents)
      0 (Virulence Factors)
      3R834EPI82 (paeonol)
      7XU7A7DROE (Amphotericin B)
      8VZV102JFY (Fluconazole)
    • Publication Date:
      Date Created: 20211007 Date Completed: 20211129 Latest Revision: 20211129
    • Publication Date:
      20231215
    • Accession Number:
      10.1080/08927014.2021.1985473
    • Accession Number:
      34615415