Chaphamaparvovirus antigen and nucleic acids are not detected in kidney tissues from cats with chronic renal disease or immunocompromised cats.

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  • Additional Information
    • Source:
      Publisher: Sage Country of Publication: United States NLM ID: 0312020 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1544-2217 (Electronic) Linking ISSN: 03009858 NLM ISO Abbreviation: Vet Pathol Subsets: MEDLINE
    • Publication Information:
      Publication: Jan. 2010- : Thousand Oaks, CA : Sage
      Original Publication: 1971- : Basel : New York : Karger.
    • Subject Terms:
      Cat Diseases* ; Nucleic Acids* ; Renal Insufficiency, Chronic*/veterinary; Animals ; Cats ; Kidney ; Mice ; Polymerase Chain Reaction/veterinary ; Retrospective Studies
    • Abstract:
      Chronic kidney disease (CKD) is a common cause of morbidity and mortality in domestic cats, but the cause is still largely elusive. While some viruses have been associated with this disease, none have been definitively implicated as causative. Recently, Rodent chaphamaparvovirus 1 was recognized as the cause of murine inclusion body nephropathy, a disease reported for over 40 years in laboratory mice. A novel virus belonging to the same genus, Carnivore chaphamaparvovirus 2, was recently identified in the feces of cats with diarrhea. The goal of this study was to investigate the possible role of chaphamaparvoviruses including members of Rodent chaphamaparvovirus 1 and Carnivore chaphamaparvovirus 2 in the development of feline CKD. The presence of these viruses was retrospectively investigated in formalin-fixed paraffin-embedded feline kidney samples using polymerase chain reaction, in situ hybridization, and immunohistochemistry. Cats were divided into 3 groups: normal ( N = 24), CKD ( N = 26), and immunocompromised ( N = 25). None of the kidney tissues from any of the 75 cats revealed the presence of chaphamaparvovirus DNA, RNA, or antigen. We conclude that viruses belonging to the chaphamaparvovirus genus are unlikely to contribute to the occurrence of feline CKD.
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    • Grant Information:
      P30 CA008748 United States CA NCI NIH HHS
    • Contributed Indexing:
      Keywords: Chaphamaparvovirus; cats; chronic kidney disease; urinary; viral
    • Accession Number:
      0 (Nucleic Acids)
    • Publication Date:
      Date Created: 20211004 Date Completed: 20220128 Latest Revision: 20240102
    • Publication Date:
      20240102
    • Accession Number:
      PMC9393070
    • Accession Number:
      10.1177/03009858211045439
    • Accession Number:
      34601998