Structural, biochemical, and functional properties of the Rap1-Interacting Adaptor Molecule (RIAM).

Publisher: Elsevier Country of Publication: United States NLM ID: 101599820 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2320-2890 (Electronic) Linking ISSN: 23194170 NLM ISO Abbreviation: Biomed J Subsets: MEDLINE

Publication: Dec. 2015- : New York : Elsevier
Original Publication: Mumbai : Medknow

Adaptor Proteins, Signal Transducing/*chemistry ; Membrane Proteins/*chemistry; Adaptor Proteins, Signal Transducing/metabolism ; Cell Adhesion ; Endothelial Cells/metabolism ; Humans ; Integrins/metabolism ; Membrane Proteins/metabolism

Leukocytes, the leading players of immune system, are involved in innate and adaptive immune responses. Leukocyte adhesion to endothelial cells during transmigration or to antigen presenting cells during T cell activation, requires integrin activation through a process termed inside-out integrin signaling. In hematopoietic cells, Rap1 and its downstream effector RIAM (Rap1-interacting adaptor molecule) form a cornerstone for inside-out integrin activation. The Rap1/RIAM pathway is involved in signal integration for activation, actin remodeling and cytoskeletal reorganization in T cells, as well as in myeloid cell differentiation and function. RIAM is instrumental for phagocytosis, a process requiring particle recognition, cytoskeletal remodeling and membrane protrusion for engulfment and digestion. In the present review, we discuss the structural and molecular properties of RIAM and the recent discoveries regarding the functional role of the Rap1/RIAM module in hematopoietic cells.
Competing Interests: Conflicts of interest VAB has patents on the PD-1 pathway licensed by Bristol-Myers Squibb, Roche, Merck, EMD-Serono, Boehringer Ingelheim, AstraZeneca, Novartis, and Dako. The authors declare no other competing interests.
(Copyright © 2022 Chang Gung University. Published by Elsevier B.V. All rights reserved.)

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Keywords: Adhesion; Integrins; Leukocytes; Phagocytosis; RIAM; Rap1

0 (APBB1IP protein, human)
0 (Adaptor Proteins, Signal Transducing)
0 (Integrins)
0 (Membrane Proteins)

Date Created: 20211003 Date Completed: 20220629 Latest Revision: 20220716

20231215

PMC9250098

10.1016/j.bj.2021.09.005

34601137