Recovery of Memory B-cell Subsets and Persistence of Antibodies in Convalescent COVID-19 Patients.

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  • Additional Information
    • Source:
      Publisher: American Society of Tropical Medicine and Hygiene Country of Publication: United States NLM ID: 0370507 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-1645 (Electronic) Linking ISSN: 00029637 NLM ISO Abbreviation: Am J Trop Med Hyg Subsets: MEDLINE
    • Publication Information:
      Publication: Northbrook, IL : American Society of Tropical Medicine and Hygiene
      Original Publication: Baltimore.
    • Subject Terms:
      Convalescence*; Antibodies, Viral/*blood ; B-Lymphocyte Subsets/*immunology ; COVID-19/*immunology ; Memory B Cells/*immunology; Acute Disease ; Adolescent ; Adult ; Aged ; Antibodies, Neutralizing/blood ; Cross-Sectional Studies ; Female ; Humans ; Immunity, Humoral ; India ; Male ; Middle Aged ; Young Adult
    • Abstract:
      It is essential to examine the longevity of the defensive immune response engendered by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. We examined the SARS-CoV-2-specific antibody responses and ex vivo memory B-cell subsets in seven groups of individuals with COVID-19 classified based on days since reverse-transcription polymerase chain reaction confirmation of SARS-CoV-2 infection. Our data showed that the levels of IgG and neutralizing antibodies started increasing from days 15 to 30 to days 61 to 90, and plateaued thereafter. The frequencies of naive B cells and atypical memory B cells decreased from days 15 to 30 to days 61 to 90, and plateaued thereafter. In contrast, the frequencies of immature B cells, classical memory B cells, activated memory B cells, and plasma cells increased from days 15 to 30 to days 61 to 90, and plateaued thereafter. Patients with severe COVID-19 exhibited increased frequencies of naive cells, atypical memory B cells, and activated memory B cells, and lower frequencies of immature B cells, central memory B cells, and plasma cells when compared with patients with mild COVID-19. Therefore, our data suggest modifications in memory B-cell subset frequencies and persistence of humoral immunity in convalescent individuals with COVID-19.
    • Accession Number:
      0 (Antibodies, Neutralizing)
      0 (Antibodies, Viral)
    • Publication Date:
      Date Created: 20210928 Date Completed: 20211228 Latest Revision: 20211228
    • Publication Date:
      20240628
    • Accession Number:
      PMC8592221
    • Accession Number:
      10.4269/ajtmh.21-0883
    • Accession Number:
      34583334