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Real-time polarization microscopy of fibrillar collagen in histopathology.
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- Additional Information
- Source:
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
- Publication Information:
Original Publication: London : Nature Publishing Group, copyright 2011-
- Subject Terms:
- Abstract:
Over the past two decades, fibrillar collagen reorganization parameters such as the amount of collagen deposition, fiber angle and alignment have been widely explored in numerous studies. These parameters are now widely accepted as stromal biomarkers and linked to disease progression and survival time in several cancer types. Despite all these advances, there has not been a significant effort to make it possible for clinicians to explore these biomarkers without adding steps to the clinical workflow or by requiring high-cost imaging systems. In this paper, we evaluate previously described polychromatic polarization microscope (PPM) to visualize collagen fibers with an optically generated color representation of fiber orientation and alignment when inspecting the sample by a regular microscope with minor modifications. This system does not require stained slides, but is compatible with histological stains such as H&E. Consequently, it can be easily accommodated as part of regular pathology review of tissue slides, while providing clinically useful insight into stromal composition.
(© 2021. The Author(s).)
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- Grant Information:
R01 CA199996 United States CA NCI NIH HHS; R01 CA238191 United States CA NCI NIH HHS; R01 GM101701 United States GM NIGMS NIH HHS; P41 GM135019 United States GM NIGMS NIH HHS
- Accession Number:
0 (Biomarkers)
0 (Fibrillar Collagens)
- Publication Date:
Date Created: 20210925 Date Completed: 20211230 Latest Revision: 20241115
- Publication Date:
20241115
- Accession Number:
PMC8463693
- Accession Number:
10.1038/s41598-021-98600-w
- Accession Number:
34561546
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