Acrylamide-derived DNA adducts in human peripheral blood mononuclear cell DNA: Correlation with body mass.

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  • Additional Information
    • Source:
      Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8207483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6351 (Electronic) Linking ISSN: 02786915 NLM ISO Abbreviation: Food Chem Toxicol Subsets: MEDLINE
    • Publication Information:
      Publication: Exeter : Elsevier Science Ltd
      Original Publication: Oxford ; New York : Pergamon Press, c1982-
    • Subject Terms:
      Acrylamide/*metabolism ; Carcinogens/*metabolism ; DNA/*metabolism ; DNA Adducts/*metabolism ; Leukocytes, Mononuclear/*metabolism; Adult ; Body Mass Index ; DNA/analysis ; DNA Adducts/analysis ; Female ; Humans ; Leukocytes, Mononuclear/chemistry ; Male ; Middle Aged ; Young Adult
    • Abstract:
      Acrylamide (AA) is a carcinogen formed during thermal food processing and can cause tumors in rodents while its carcinogenic potency in humans is unclear. Metabolic conversion of AA leads to glycidamide (GA) forming N7-GA-guanine (N7-GA-Gua) as the major DNA adduct in rodents while no such adducts were found in human tissues so far. In a cohort of 56 healthy volunteers adduct levels were determined in peripheral blood mononuclear cell (PBMC) DNA and anthropometric, dietary, and biochemical parameters were measured or inquired using a questionnaire. In the majority of PBMC DNA samples the levels found were above one adduct/10 8 nucleosides not being correlated to dietary habits including coffee consumption, or to blood glucose levels or hemoglobin HbA1c. However, adduct levels were significantly correlated with the body mass index (BMI) and showed a continuous increase over three BMI classes. Our findings indicate a background of AA-derived DNA adducts present in humans in PBMC related to body mass rather than to certain dietary or lifestyle factors.
      (Copyright © 2021 Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: Acrylamide; DNA adducts; Glycidamide; Human; Mononuclear blood cells
    • Accession Number:
      0 (Carcinogens)
      0 (DNA Adducts)
      20R035KLCI (Acrylamide)
      9007-49-2 (DNA)
    • Publication Date:
      Date Created: 20210924 Date Completed: 20220209 Latest Revision: 20220209
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/j.fct.2021.112575
    • Accession Number:
      34560178