IgA Nephropathy as the Initial Presentation of Celiac Disease in an Adolescent.

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  • Author(s): Slavin SF;Slavin SF
  • Source:
    Pediatrics [Pediatrics] 2021 Oct; Vol. 148 (4). Date of Electronic Publication: 2021 Sep 09.
  • Publication Type:
    Case Reports; Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Academy of Pediatrics Country of Publication: United States NLM ID: 0376422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-4275 (Electronic) Linking ISSN: 00314005 NLM ISO Abbreviation: Pediatrics Subsets: MEDLINE
    • Publication Information:
      Publication: Elk Grove Village Il : American Academy of Pediatrics
      Original Publication: Springfield, Ill., Thomas.
    • Subject Terms:
      Diet, Gluten-Free*; Celiac Disease/*complications ; Glomerulonephritis, IGA/*etiology; Adolescent ; Celiac Disease/diagnosis ; Celiac Disease/diet therapy ; Creatinine/blood ; Hematuria/etiology ; Humans ; Male ; Proteinuria/etiology
    • Abstract:
      Immunoglobulin A (IgA) nephropathy (Berger's disease) is the most common glomerulonephritis worldwide. The disease typically is chronic and lifelong and eventually progresses to impaired renal function in a substantial proportion of cases. It has been known for some time that there is a correlation between IgA nephropathy and celiac disease, but until now it has remained unclear whether treatment of the underlying celiac disease has any meaningful impact on the progression of the renal disease. Therefore, until now, screening for celiac disease in patients presenting with IgA nephropathy has not been universally recommended in the absence of suggestive gastrointestinal symptoms. This report describes a case of IgA nephropathy in an adolescent boy that turned out to be the initial presentation of celiac disease. More importantly, it documents the complete laboratory normalization of his renal anomalies at 5-year follow-up after treatment of his celiac disease with implementation of a gluten-free diet. This case highlights the importance of awareness that suspected IgA nephropathy, even in the absence of gastrointestinal symptoms, should prompt screening for underlying celiac disease as a potential, and possibly treatable, cause.
      Competing Interests: POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no conflicts of interest relevant to this article to disclose.
      (Copyright © 2021 by the American Academy of Pediatrics.)
    • Accession Number:
      AYI8EX34EU (Creatinine)
    • Publication Date:
      Date Created: 20210910 Date Completed: 20211217 Latest Revision: 20211217
    • Publication Date:
      20221213
    • Accession Number:
      10.1542/peds.2021-051332
    • Accession Number:
      34504037