Potential Roles of Exosomal lncRNAs in the Intestinal Mucosal Immune Barrier.

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  • Author(s): Chen S;Chen S; He R; He R; He B; He B; Xu L; Xu L; Zhang S; Zhang S
  • Source:
    Journal of immunology research [J Immunol Res] 2021 Aug 25; Vol. 2021, pp. 7183136. Date of Electronic Publication: 2021 Aug 25 (Print Publication: 2021).
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Hindawi Publishing Corporation Country of Publication: Egypt NLM ID: 101627166 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-7156 (Electronic) Linking ISSN: 23147156 NLM ISO Abbreviation: J Immunol Res Subsets: MEDLINE
    • Publication Information:
      Original Publication: Cairo, Egypt : Hindawi Publishing Corporation, [2014]-
    • Subject Terms:
      Exosomes/*metabolism ; Immunity, Mucosal/*genetics ; Intestinal Diseases/*immunology ; Intestinal Mucosa/*immunology ; RNA, Long Noncoding/*metabolism; Animals ; Disease Models, Animal ; Gene Expression Regulation/immunology ; Humans ; Intestinal Diseases/diagnosis ; Intestinal Diseases/genetics ; Intestinal Diseases/pathology ; Intestinal Mucosa/cytology ; Intestinal Mucosa/pathology ; Severity of Illness Index
    • Abstract:
      The intestinal mucosal immune barrier protects the host from the invasion of foreign pathogenic microorganisms. Immune cells and cytokines in the intestinal mucosa maintain local and systemic homeostasis by participating in natural and adaptive immunity. Deficiency of the intestinal mucosal immune barrier is associated with a variety of intestinal illnesses. Exosomes are phospholipid bilayer nanovesicles that allow cell-cell communication by secreting physiologically active substances including proteins, lipids, transcription factors, mRNAs, micro-RNAs (miRNAs), and long noncoding RNAs (lncRNAs). Exosomal lncRNAs are involved in immune cell differentiation and the modulation of the immune response. This review briefly introduces the potential role of exosomal lncRNAs in the intestinal mucosal immune barrier and discusses their relevance to intestinal illnesses.
      Competing Interests: All the authors declare that they have no conflict of interest.
      (Copyright © 2021 Shanshan Chen et al.)
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    • Accession Number:
      0 (RNA, Long Noncoding)
    • Publication Date:
      Date Created: 20210906 Date Completed: 20220124 Latest Revision: 20220124
    • Publication Date:
      20221213
    • Accession Number:
      PMC8413039
    • Accession Number:
      10.1155/2021/7183136
    • Accession Number:
      34485536