[Arthritis and pulmonary cavities].

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  • Additional Information
    • Transliterated Title:
      Arthritiden und Lungenkavernen.
    • Source:
      Publisher: Springer Country of Publication: Germany NLM ID: 0414162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-1250 (Electronic) Linking ISSN: 03401855 NLM ISO Abbreviation: Z Rheumatol Subsets: MEDLINE
    • Publication Information:
      Publication: 2006- : Heidelberg : Springer
      Original Publication: Darmstadt, Steinkopff.
    • Subject Terms:
      Arthritis*/drug therapy ; Granulomatosis with Polyangiitis*/diagnosis ; Granulomatosis with Polyangiitis*/drug therapy; Antibodies, Antineutrophil Cytoplasmic ; Cyclophosphamide/therapeutic use ; Glucocorticoids/therapeutic use ; Humans ; Methotrexate/therapeutic use
    • Abstract:
      This case report describes the very rare simultaneous occurrence of rheumatoid arthritis and granulomatosis with polyangiitis with the only organ manifestation of life-threatening bilateral pulmonary cavities. Due to the acuteness of the vasculitis, treatment was primarily with cyclophosphamide infusions and high-dose glucocorticoids, and in the further course with high-dose methotrexate. Routine thoracic imaging also seems to be useful when conventional basic rheumatologic treatment is newly initiated, as treatment-decisive changes are seen with a relevant frequency. The occurrence of both autoimmune diseases might be due to common genetic predispositions.
      (© 2021. Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
    • References:
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    • Contributed Indexing:
      Keywords: Cavitary lung disease; Differential diagnosis; Granulomatosis with polyangiitis; PR3-ANCA; Rheumatoid arthritis
      Local Abstract: [Publisher, German] Dieser Fallbericht beschreibt das sehr seltene gleichzeitige Auftreten einer rheumatoiden Arthritis und einer Granulomatose mit Polyangiitis mit der einzigen Organmanifestation lebensbedrohlicher Lungenkavitäten beidseitig. Die Therapie erfolgte aufgrund der Akuität der Erkrankung primär mit Cyclophosphamid-Infusionen und hoch dosierten Glukokortikoiden, im weiteren Verlauf mit hoch dosiertem Methotrexat. Auch bei Neueinleitung einer konventionellen rheumatologischen Basistherapie scheint eine routinemäßige Thoraxaufnahme sinnvoll zu sein, da in relevanter Häufigkeit therapieentscheidende Veränderungen gesehen werden. Das Auftreten beider Autoimmunerkrankungen könnte auf gemeinsame genetische Prädispositionen zurückzuführen sein.
    • Accession Number:
      0 (Antibodies, Antineutrophil Cytoplasmic)
      0 (Glucocorticoids)
      8N3DW7272P (Cyclophosphamide)
      YL5FZ2Y5U1 (Methotrexate)
    • Publication Date:
      Date Created: 20210824 Date Completed: 20221006 Latest Revision: 20221006
    • Publication Date:
      20240829
    • Accession Number:
      10.1007/s00393-021-01064-6
    • Accession Number:
      34427736