Trends in Prevalence of Type 1 and Type 2 Diabetes in Children and Adolescents in the US, 2001-2017.

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  • Additional Information
    • Corporate Authors:
      SEARCH for Diabetes in Youth Study Group
    • Source:
      Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
    • Publication Information:
      Original Publication: Chicago : American Medical Association, 1960-
    • Subject Terms:
      Diabetes Mellitus, Type 1/*epidemiology ; Diabetes Mellitus, Type 2/*epidemiology; Adolescent ; Child ; Child, Preschool ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/ethnology ; Diabetes Mellitus, Type 2/ethnology ; Female ; Humans ; Male ; Prevalence ; United States/epidemiology ; Young Adult
    • Abstract:
      Importance: Changes in the prevalence of youth-onset diabetes have previously been observed.
      Objective: To estimate changes in prevalence of type 1 and type 2 diabetes in youths in the US from 2001 to 2017.
      Design, Setting, and Participants: In this cross-sectional observational study, individuals younger than 20 years with physician-diagnosed diabetes were enumerated from 6 areas in the US (4 geographic areas, 1 health plan, and select American Indian reservations) for 2001, 2009, and 2017.
      Exposures: Calendar year.
      Main Outcomes and Measures: Estimated prevalence of physician-diagnosed type 1 and type 2 diabetes overall and by race and ethnicity, age, and sex.
      Results: Among youths 19 years or younger, 4958 of 3.35 million had type 1 diabetes in 2001, 6672 of 3.46 million had type 1 diabetes in 2009, and 7759 of 3.61 million had type 1 diabetes in 2017; among those aged 10 to 19 years, 588 of 1.73 million had type 2 diabetes in 2001, 814 of 1.85 million had type 2 diabetes in 2009, and 1230 of 1.85 million had type 2 diabetes in 2017. The estimated type 1 diabetes prevalence per 1000 youths for those 19 years or younger increased significantly from 1.48 (95% CI, 1.44-1.52) in 2001 to 1.93 (95% CI, 1.88-1.98) in 2009 to 2.15 (95% CI, 2.10-2.20) in 2017, an absolute increase of 0.67 per 1000 youths (95%, CI, 0.64-0.70) and a 45.1% (95% CI, 40.0%-50.4%) relative increase over 16 years. The greatest absolute increases were observed among non-Hispanic White (0.93 per 1000 youths [95% CI, 0.88-0.98]) and non-Hispanic Black (0.89 per 1000 youths [95% CI, 0.88-0.98]) youths. The estimated type 2 diabetes prevalence per 1000 youths aged 10 to 19 years increased significantly from 0.34 (95% CI, 0.31-0.37) in 2001 to 0.46 (95% CI, 0.43-0.49) in 2009 to 0.67 (95% CI, 0.63-0.70) in 2017, an absolute increase of 0.32 per 1000 youths (95% CI, 0.30-0.35) and a 95.3% (95% CI, 77.0%-115.4%) relative increase over 16 years. The greatest absolute increases were observed among non-Hispanic Black (0.85 per 1000 youths [95% CI, 0.74-0.97]) and Hispanic (0.57 per 1000 youths [95% CI, 0.51-0.64]) youths.
      Conclusions and Relevance: In 6 areas of the US from 2001 to 2017, the estimated prevalence of diabetes among children and adolescents increased for both type 1 and type 2 diabetes.
    • Comments:
      Erratum in: JAMA. 2021 Oct 5;326(13):1331. (PMID: 34609472)
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    • Grant Information:
      UL1 TR000062 United States TR NCATS NIH HHS; UL1 TR001425 United States TR NCATS NIH HHS; U01 DP000244 United States DP NCCDPHP CDC HHS; U18 DP006131 United States DP NCCDPHP CDC HHS; U01 DP000250 United States DP NCCDPHP CDC HHS; U18 DP006138 United States DP NCCDPHP CDC HHS; U18 DP006136 United States DP NCCDPHP CDC HHS; UL1 TR000077 United States TR NCATS NIH HHS; U01 DP000254 United States DP NCCDPHP CDC HHS; U18 DP002708 United States DP NCCDPHP CDC HHS; P30 DK057516 United States DK NIDDK NIH HHS; K23 HL148394 United States HL NHLBI NIH HHS; R01 DK127208 United States DK NIDDK NIH HHS; UC4 DK108173 United States DK NIDDK NIH HHS; U18 DP006133 United States DP NCCDPHP CDC HHS; L40 HL148910 United States HL NHLBI NIH HHS; UL1 TR000423 United States TR NCATS NIH HHS; U18 DP006139 United States DP NCCDPHP CDC HHS; U18 DP006134 United States DP NCCDPHP CDC HHS
    • Publication Date:
      Date Created: 20210824 Date Completed: 20210916 Latest Revision: 20220907
    • Publication Date:
      20221213
    • Accession Number:
      PMC8385600
    • Accession Number:
      10.1001/jama.2021.11165
    • Accession Number:
      34427600