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Evaluation of the Abbott Panbio TM COVID-19 Ag rapid antigen test for the detection of SARS-CoV-2 in asymptomatic Canadians.
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- Author(s): Shaw JLV;Shaw JLV;Shaw JLV;Shaw JLV; Deslandes V; Deslandes V; Deslandes V; Deslandes V; Smith J; Smith J; Desjardins M; Desjardins M; Desjardins M; Desjardins M
- Source:
Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2021 Dec; Vol. 101 (4), pp. 115514. Date of Electronic Publication: 2021 Jul 31.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8305899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0070 (Electronic) Linking ISSN: 07328893 NLM ISO Abbreviation: Diagn Microbiol Infect Dis Subsets: MEDLINE
- Publication Information: Original Publication: [New York, NY] : Elsevier Biomedical, [c1983-
- Subject Terms: Asymptomatic Infections*; COVID-19/*virology ; COVID-19 Serological Testing/*methods ; COVID-19 Testing/*methods ; SARS-CoV-2/*isolation & purification; COVID-19/diagnosis ; Canada ; Humans ; Immunologic Tests ; Nasopharynx/virology ; Predictive Value of Tests ; Prospective Studies ; Sensitivity and Specificity
- Abstract: Several rapid testing methodologies have been approved for testing of symptomatic individuals but have not been validated for asymptomatic screening. We evaluated performance of the Abbott PanbioTM COVID-19 rapid antigen assay in the asymptomatic setting. We conducted a prospective study in an urban assessment center and in the context of long-term care staff screening. A total of 3014 individuals submitted paired nasopharyngeal samples, which were tested in parallel with the rapid antigen and laboratory-based, RT-PCR assays SARS-CoV-2 detection. There was 54.5% concordance in positive results between the rapid antigen assay and RT-PCR. All positive rapid antigen assay results were confirmed by RT-PCR. The negative predictive value of the rapid antigen assay minimally improved on the negative pre-test probability of SARS-CoV-2 infection. The Abbott PanbioTM COVID-19 rapid antigen test allowed for faster identification of infected individuals but cannot be used to rule-out SARS-CoV-2 infection.
Competing Interests: Declaration of Competing Interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. J. Shaw has served as an Advisory Board Member for Abbott
(Copyright © 2021 Elsevier Inc. All rights reserved.) - References: Euro Surveill. 2020 Jan;25(3):. (PMID: 31992387)
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CMAJ. 2021 Mar 29;193(13):E449-E452. (PMID: 33658247)
Can Commun Dis Rep. 2021 Jan 29;47(1):17-22. (PMID: 33767600)
Clin Microbiol Infect. 2021 Apr;27(4):636.e1-636.e4. (PMID: 33421573)
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N Engl J Med. 2020 May 28;382(22):2081-2090. (PMID: 32329971) - Contributed Indexing: Keywords: Asymptomatic screening; Covid-19; Laboratory oversight; Point of care testing; Quality assurance; Rapid antigen
- Publication Date: Date Created: 20210821 Date Completed: 20211110 Latest Revision: 20221221
- Publication Date: 20240628
- Accession Number: PMC8324400
- Accession Number: 10.1016/j.diagmicrobio.2021.115514
- Accession Number: 34418823
- Source:
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