Chemical studies on Mexican plants used in traditional medicine, III: New 4-phenylcoumarins from Exostema caribaeum.

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  • Author(s): Mata R;Mata R; Calzada F; Garcia MR; Reguero MT
  • Source:
    Journal of natural products [J Nat Prod] 1987 Sep-Oct; Vol. 50 (5), pp. 866-71.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print Cited Medium: Print ISSN: 0163-3864 (Print) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE
    • Publication Information:
      Original Publication: Cincinnati, American Society of Pharmacognosy.
    • Subject Terms:
      Coumarins/*analysis ; Plants, Medicinal/*analysis; Acetylation ; Chemical Phenomena ; Chemistry ; Hydrolysis ; Magnetic Resonance Spectroscopy ; Mexico
    • Abstract:
      Investigation of the MeOH extract of Exostema caribaeum (Rubiaceae) led to the isolation of three new 4-phenylcoumarins. Their structures, 5-O-beta-D-galactosyl-7-methoxy-3',4'-dihydroxy-4-phenylcoumarin [1a] 7,4',5'-trihydroxy-4-phenyl-5,2'-oxidocoumarin [2a] and 7,4'-dimethoxy-5'-hydroxy-4-phenyl-5,2'-oxido-coumarin [3a] were elucidated by spectral methods and chemical transformations. It was also demonstrated that 4-phenylcoumarins undergo oxidative cyclization under basic conditions in the presence of air to give 4-phenyl-5,2'-oxido-coumarins.
    • Accession Number:
      0 (Coumarins)
    • Publication Date:
      Date Created: 19870901 Date Completed: 19880325 Latest Revision: 20190903
    • Publication Date:
      20240829
    • Accession Number:
      10.1021/np50053a015
    • Accession Number:
      3437283