Trajectory of the incidence of brushes on preterm electroencephalogram and its association with neurodevelopment in extremely low birth weight infants.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7131 (Electronic) Linking ISSN: 03877604 NLM ISO Abbreviation: Brain Dev Subsets: MEDLINE
    • Publication Information:
      Publication: 1993- : Amsterdam : Elsevier
      Original Publication: Tokyo, B & D Publishing Society.
    • Subject Terms:
      Electroencephalography*; Brain Diseases/*physiopathology ; Developmental Disabilities/*physiopathology ; Infant, Extremely Low Birth Weight/*physiology ; Infant, Premature/*physiology ; White Matter/*pathology; Brain Diseases/diagnostic imaging ; Brain Diseases/pathology ; Female ; Humans ; Infant, Newborn ; Magnetic Resonance Imaging ; Male ; White Matter/diagnostic imaging
    • Abstract:
      Background: Brush or delta brush is a well-known characteristic waveform in preterm electroencephalograms. However, the longitudinal trajectory of brushes and its association with neurodevelopment remain uncertain.
      Methods: We analyzed the longitudinal incidence of brushes in 36 extremely low birth weight infants without severe brain lesions and its association with neurodevelopment and white matter abnormality. Conventional eight-channel electroencephalograms were recorded at 30, 32, 36, and 40 postmenstrual weeks (PMW). Incidence of brushes was calculated as the sum of brushes from each channel separated by active sleep and quiet sleep. A developmental delay was defined as a developmental quotient of <85 assessed at corrected age of 18 months. White matter abnormalities were evaluated with term-equivalent magnetic resonance imaging.
      Results: The median incidence of brushes (per minute) in 36 infants at PMW 30, 32, 36, and 40 was 16.4, 20.4, 22.5, and 1.8 during active sleep and 7.5, 10.3, 11.5, and 1.7 during quiet sleep, respectively. Among the 36 infants, 14 infants were diagnosed with developmental delay. Longitudinal trajectories of the incidence of brushes were different between the normal and the delayed development groups. Brushes were observed most frequently at 36 PMW in the delayed development group. The incidence of brushes at 36 PMW was significantly correlated with the severity of white matter abnormalities and negatively correlated with the developmental quotient.
      Conclusion: The incidence of brushes at 36 PMW can be a unique predictor of early neurodevelopment in extremely low birth weight infants without severe brain lesions.
      (Copyright © 2021 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Brush; Delta brush; Neurodevelopment; Subplate neuron; White matter abnormality
    • Publication Date:
      Date Created: 20210802 Date Completed: 20220221 Latest Revision: 20220221
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.braindev.2021.07.003
    • Accession Number:
      34334244