Seroprevalence estimate and risk factors for Coxiella burnetii infections among humans in a highly urbanised Brazilian state.

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  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 7506129 Publication Model: Print Cited Medium: Internet ISSN: 1878-3503 (Electronic) Linking ISSN: 00359203 NLM ISO Abbreviation: Trans R Soc Trop Med Hyg Subsets: MEDLINE
    • Publication Information:
      Publication: 2013- : Oxford : Oxford University Press
      Original Publication: 1920- : London : Royal Society of Tropical Medicine and Hygiene
    • Subject Terms:
      Coxiella burnetii* ; Q Fever*/epidemiology ; Q Fever*/etiology; Animals ; Antibodies, Bacterial ; Brazil/epidemiology ; Humans ; Livestock ; Risk Factors ; Seroepidemiologic Studies ; Zoonoses
    • Abstract:
      Background: Q fever is among the top 13 global priority zoonoses, however, it is still neglected and under-reported in most of the world, including Brazil. Thus, we evaluated the seroprevalence of and the risk factors for Coxiella burnetii infections in humans from Minas Gerais, a highly urbanised Brazilian state.
      Methods: Coxiella burnetii was searched for patient samples (n=437), which were suspected of then later confirmed as negative for dengue fever, by the indirect immunofluorescence technique and real-time PCR. Risk factors for infections and spatial clusters for both C. burnetii-seropositive individuals and livestock concentration were evaluated.
      Results: We found that 21 samples (4.8%; 95% CI 3.0 to 7.2%) were reactive for at least one class of anti-C. burnetii antibodies (titer of ≥64), with rural residence (p=0.036) being a risk factor. Also, two spatial clusters of seropositivity were found within a significant area by Scan, and a probable relationship between the Scan result and the livestock concentration by area was found.
      Conclusions: Seropositive individuals were associated with rural residence, with a likely relationship with the livestock concentration. Thus, this study establishes baseline figures for C. burnetii seroprevalence in humans in a state of Brazil, allowing the monitoring of trends and setting of control targets, as well as more representative longitudinal and risk analysis studies.
      (© The Author(s) 2021. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.)
    • Contributed Indexing:
      Keywords: Coxiella burnetii, public health; Q fever; seroprevalence; zoonosis
    • Accession Number:
      0 (Antibodies, Bacterial)
    • Publication Date:
      Date Created: 20210726 Date Completed: 20220429 Latest Revision: 20220429
    • Publication Date:
      20250114
    • Accession Number:
      10.1093/trstmh/trab113
    • Accession Number:
      34308483