Biological insights into the piericidin family of microbial metabolites.

Publisher: Oxford University Press Country of Publication: England NLM ID: 9706280 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2672 (Electronic) Linking ISSN: 13645072 NLM ISO Abbreviation: J Appl Microbiol Subsets: MEDLINE

Publication: 2022- : Oxford : Oxford University Press
Original Publication: Oxford : Published for the Society for Applied Bacteriology by Blackwell Science, c1997-

Anti-Bacterial Agents*/pharmacology ; Antineoplastic Agents*/pharmacology ; Streptomyces*/chemistry ; Streptomyces*/genetics; Pyridines/*pharmacology; Multigene Family

Extensively produced by members of the genus Streptomyces, piericidins are a large family of microbial metabolites, which consist of main skeleton of 4-pyridinol with methylated polyketide side chain. Nonetheless, these metabolites show differences in their bioactive potentials against micro-organisms, insects and tumour cells. Due to its close structural similarity with coenzyme Q, piericidins also possess an inhibitory activity against NADH dehydrogenase as well as Photosystem II. This review studied the latest research progress of piericidins, covering the chemical structure and physical properties of newly identified members, bioactivities, biosynthetic pathway with gene clusters and future prospect. With the increasing incidence of drug-resistant human pathogen strains and cancers, this review aimed to provide clues for the development of either new potential antibiotics or anti-tumour agents.
(© 2021 The Society for Applied Microbiology.)

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Keywords: Streptomyces; Piericidin; anti-tumour activity; antimicrobial activity; biosynthetic pathway; insecticidal activity

0 (Anti-Bacterial Agents)
0 (Antineoplastic Agents)
0 (Pyridines)

Date Created: 20210714 Date Completed: 20220121 Latest Revision: 20220531

20221213

10.1111/jam.15222

34260807