Therapeutic antagonism between anticholinergics and neuroleptics: possible involvement of cholinergic mechanisms in schizophrenia.

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  • Author(s): Mohan M; Kay SR
  • Source:
    Schizophrenia bulletin [Schizophr Bull] 1978; Vol. 4 (1), pp. 3-6.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: United States NLM ID: 0236760 Publication Model: Print Cited Medium: Print ISSN: 0586-7614 (Print) Linking ISSN: 05867614 NLM ISO Abbreviation: Schizophr Bull Subsets: MEDLINE
    • Publication Information:
      Publication: 2005- : Cary, NC : Oxford University Press
      Original Publication: [Chevy Chase, Md., For sale by the Supt. of Docs., U. S. Govt. Print. Off. Washington]
    • Subject Terms:
      Antipsychotic Agents/*antagonists & inhibitors ; Antipsychotic Agents/*therapeutic use ; Parasympatholytics/*therapeutic use ; Receptors, Cholinergic/*drug effects ; Schizophrenia/*drug therapy; Cholinergic Fibers/physiopathology ; Drug Antagonism ; Drug Therapy, Combination ; Humans ; Receptors, Dopamine/drug effects ; Research Design ; Schizophrenia/physiopathology
    • Abstract:
      We have answered technical criticisms of our work in which anticholinergic agents were added to ongoing neuroleptic treatment in an ABA' research design. The suggested analysis of variance for repeated measures of the three periods is inappropriate because of the expected carryover effects from continuous neuroleptic treatment. The multivariate analysis of various parameters seems unsuitable because homogeneity of covariance cannot be ensured due to the heterogeneity of schizophrenia and the diverse factors represented in the psychopathology measures. We have summarized the results of recent parametric and nonparametric analyses of combined data from our three studies to show that the significant effects clearly pointed to therapeutic antagonism between anticholinergic agents and neuroleptics. We suggest that cholinergic neurons may be part of some crucial discriminative control mechanisms in the brain organization that are ineffective in schizophrenia and lead to a relative overactivity of the opposing catecholaminergic neurons in the midbrain-limbic circuitry which promote repetition of behaviors in goal-directed activity.
    • Accession Number:
      0 (Antipsychotic Agents)
      0 (Parasympatholytics)
      0 (Receptors, Cholinergic)
      0 (Receptors, Dopamine)
    • Publication Date:
      Date Created: 19780101 Date Completed: 19790516 Latest Revision: 20190509
    • Publication Date:
      20231215
    • Accession Number:
      10.1093/schbul/4.1.3
    • Accession Number:
      34209