Functionalization of Photosensitized Silica Nanoparticles for Advanced Photodynamic Therapy of Cancer.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Nanoparticles* ; Photochemotherapy* ; Rose Bengal*; Neoplasms/*drug therapy ; Silicon Dioxide/*administration & dosage; Drug Screening Assays, Antitumor ; Folic Acid ; HeLa Cells ; Humans ; Polyethylene Glycols

BODIPY dyes have recently attracted attention as potential photosensitizers. In this work, commercial and novel photosensitizers (PSs) based on BODIPY chromophores (haloBODIPYs and orthogonal dimers strategically designed with intense bands in the blue, green or red region of the visible spectra and high singlet oxygen production) were covalently linked to mesoporous silica nanoparticles (MSNs) further functionalized with PEG and folic acid (FA). MSNs approximately 50 nm in size with different functional groups were synthesized to allow multiple alternatives of PS-PEG-FA decoration of their external surface. Different combinations varying the type of PS (commercial Rose Bengal, Thionine and Chlorine e6 or custom-made BODIPY-based), the linkage design, and the length of PEG are detailed. All the nanosystems were physicochemically characterized (morphology, diameter, size distribution and PS loaded amount) and photophysically studied (absorption capacity, fluorescence efficiency, and singlet oxygen production) in suspension. For the most promising PS-PEG-FA silica nanoplatforms, the biocompatibility in dark conditions and the phototoxicity under suitable irradiation wavelengths (blue, green, or red) at regulated light doses (10-15 J/cm ² ) were compared with PSs free in solution in HeLa cells in vitro.

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IT912-16 Eusko Jaurlaritza; IT-1302-19 Eusko Jaurlaritza; MAT2017-83856-C3-2-P Ministerio de Economía, Industria y Competitividad, Gobierno de España; MAT2017-83856-C3-3-P Ministerio de Economía, Industria y Competitividad, Gobierno de España; PID2020-114755GB-C3 Ministerio de Economía, Industria y Competitividad, Gobierno de España; CTM2016-81130-R Ministerio de Economía, Industria y Competitividad, Gobierno de España; COLAB19/01 Euskal Herriko Unibertsitatea

Keywords: (photo) toxicity; BODIPY-based photosensitizers; HeLa cells; PEG; folic acid; functionalized silica nanoparticles; photodynamic therapy

1ZPG1ELY14 (Rose Bengal)
3WJQ0SDW1A (Polyethylene Glycols)
7631-86-9 (Silicon Dioxide)
935E97BOY8 (Folic Acid)

Date Created: 20210702 Date Completed: 20210802 Latest Revision: 20240402

20240402

PMC8234454

10.3390/ijms22126618

34205599