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The Role of Renal Macrophage, AIM, and TGF-β1 Expression in Renal Fibrosis Progression in IgAN Patients.
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- Author(s): Yang M;Yang M; Liu JW; Liu JW; Zhang YT; Zhang YT; Wu G; Wu G
- Source:
Frontiers in immunology [Front Immunol] 2021 Jun 14; Vol. 12, pp. 646650. Date of Electronic Publication: 2021 Jun 14 (Print Publication: 2021).- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
- Publication Information: Original Publication: [Lausanne : Frontiers Research Foundation]
- Subject Terms: Apoptosis Regulatory Proteins/*immunology ; Glomerulonephritis, IGA/*immunology ; Kidney/*immunology ; Macrophages/*immunology ; Receptors, Scavenger/*immunology ; Transforming Growth Factor beta1/*immunology; Analysis of Variance ; Apoptosis Regulatory Proteins/metabolism ; Female ; Fibrosis ; Fluorescent Antibody Technique/methods ; Glomerulonephritis, IGA/metabolism ; Glomerulonephritis, IGA/pathology ; Humans ; Immunohistochemistry/methods ; Kidney/metabolism ; Kidney/pathology ; Macrophages/classification ; Male ; Receptors, Scavenger/metabolism ; Transforming Growth Factor beta1/metabolism
- Abstract: Objective: To analyze the expression of macrophages, AIM, TGF-β1 in the kidney of IgAN patients, and to explore the role of macrophages, AIM, TGF-β1 in the progression of renal fibrosis in IgAN patients.
Methods: The paraffin specimens of renal tissue from 40 IgAN patients were selected as the observation group. At the same time, paraffin specimens of normal renal tissue from 11 patients treated by nephrectomy were selected as the normal control group. We observed the distribution of macrophages, the expression of AIM and TGF-β1 by immunohistochemical staining and/or immunofluorescence.
Result: The number of M0, M1, M2 macrophages could be found increased in IgAN patients. M0 macrophages are mainly polarized towards M2 macrophages. The expression of AIM and TGF-β1 were significantly higher in IgAN patients than in NC. M2 macrophage, AIM and TGF-β1 were positively correlated with serum creatinine and 24-hour proteinuria, but negatively correlated with eGFR. M2 macrophages, AIM, TGF-β1 were positively correlated with fibrotic area.
Conclusion: M2 macrophages, AIM and TGF-β1 play important roles in the process of IgAN fibrosis, and the three influence each other.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2021 Yang, Liu, Zhang and Wu.) - References: Clin Immunol. 2016 Nov;172:72-77. (PMID: 27444044)
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Nat Med. 2016 Feb;22(2):183-93. (PMID: 26726878) - Contributed Indexing: Keywords: AIM; IgAN; TGF-β1; macrophage; renal fibrosis
- Accession Number: 0 (Apoptosis Regulatory Proteins)
0 (CD5L protein, human)
0 (Receptors, Scavenger)
0 (TGFB1 protein, human)
0 (Transforming Growth Factor beta1) - Publication Date: Date Created: 20210701 Date Completed: 20210927 Latest Revision: 20210927
- Publication Date: 20240628
- Accession Number: PMC8236720
- Accession Number: 10.3389/fimmu.2021.646650
- Accession Number: 34194427
- Source:
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