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Cigarette smoking may accelerate the progression of IgA nephropathy.
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- Author(s): Wang S;Wang S;Wang S; Qin A; Qin A; Qin A; Pei G; Pei G; Pei G; Jiang Z; Jiang Z; Jiang Z; Dong L; Dong L; Dong L; Tan J; Tan J; Tan J; Tan L; Tan L; Tan L; Tang Y; Tang Y; Tang Y; Qin W; Qin W; Qin W
- Source:
BMC nephrology [BMC Nephrol] 2021 Jun 29; Vol. 22 (1), pp. 239. Date of Electronic Publication: 2021 Jun 29.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: BioMed Central Country of Publication: England NLM ID: 100967793 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2369 (Electronic) Linking ISSN: 14712369 NLM ISO Abbreviation: BMC Nephrol Subsets: MEDLINE
- Publication Information: Original Publication: London : BioMed Central, [2000-
- Subject Terms: Disease Progression*; Cigarette Smoking/*adverse effects ; Glomerulonephritis, IGA/*complications; Adult ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Glomerulonephritis, IGA/physiopathology ; Humans ; Hypertension/complications ; Kaplan-Meier Estimate ; Kidney Failure, Chronic/etiology ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Propensity Score ; Proportional Hazards Models ; Renal Replacement Therapy ; Retrospective Studies ; Risk Factors
- Abstract: Background: Whether cigarette smoking is associated with the progression of immunoglobulin A nephropathy (IgAN) remains uncertain; therefore, we aimed to evaluate the effect of cigarette smoking on the prognosis of IgAN.
Methods: We divided 1239 IgAN patients from West China Hospital of Sichuan University who met the inclusion criteria into smoker (current or former) and non-smoker groups. The endpoint was end-stage renal disease (ESRD: eGFR < 15 mL/min/1.73 m 2 or undergoing renal replacement treatment) and/or eGFR decreased by > 50%. Kaplan-Meier, correlation, logistic regression and Cox proportional hazards analyses were performed. The association between cigarette smoking and IgAN was further verified by propensity-score-matched cohort analysis.
Results: During the mean follow-up period of 61 months, 19% (40/209) of the smoker group and 11% (110/1030) of the non-smoker group reached the study endpoint (p < 0.001). Multivariate Cox regression analysis revealed that cigarette smoking (hazard ratio (HR) = 1.58; p = 0.043) was an independent risk factor predicting poor renal progression in IgAN, and that IgAN patients with chronic kidney disease (CKD) stage 3-4 were more susceptible to cigarette smoking (p < 0.001). After propensity score matching (PSM), a significant correlation between cigarette smoking and renal outcomes in IgAN patients was seen. Furthermore, Spearman's correlation test revealed that smoking dose was negatively correlated with eGFR (r = 0.141; p < 0.001) and positively related with proteinuria (r = 0.096; p = 0.001).
Conclusions: Cigarette smoking is an independent risk factor for IgAN progression, especially for advanced patients. - References: APMIS. 2016 May;124(5):393-400. (PMID: 26848794)
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Am J Physiol Renal Physiol. 2010 Oct;299(4):F732-9. (PMID: 20685820) - Contributed Indexing: Keywords: Cigarette smoking; IgA nephropathy; Propensity score matching; Renal survival
- Publication Date: Date Created: 20210630 Date Completed: 20220207 Latest Revision: 20220207
- Publication Date: 20240628
- Accession Number: PMC8244187
- Accession Number: 10.1186/s12882-021-02453-4
- Accession Number: 34187402
- Source:
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