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Efficacy and Safety of Dapagliflozin by Baseline Glycemic Status: A Prespecified Analysis From the DAPA-CKD Trial.
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- Author(s): Persson F;Persson F; Rossing P; Rossing P; Rossing P; Vart P; Vart P; Chertow GM; Chertow GM; Hou FF; Hou FF; Jongs N; Jongs N; McMurray JJV; McMurray JJV; Correa-Rotter R; Correa-Rotter R; Bajaj HS; Bajaj HS; Stefansson BV; Stefansson BV; Toto RD; Toto RD; Langkilde AM; Langkilde AM; Wheeler DC; Wheeler DC; Wheeler DC; Heerspink HJL
- Source:
Diabetes care [Diabetes Care] 2021 Aug; Vol. 44 (8), pp. 1894-1897. Date of Electronic Publication: 2021 Jun 28.- Publication Type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Corporate Authors:
- Source: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 7805975 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1935-5548 (Electronic) Linking ISSN: 01495992 NLM ISO Abbreviation: Diabetes Care Subsets: MEDLINE
- Publication Information: Publication: Alexandria Va : American Diabetes Association
Original Publication: New York, American Diabetes Assn. - Subject Terms: Cardiovascular Diseases*/epidemiology ; Cardiovascular Diseases*/prevention & control ; Diabetes Mellitus, Type 2*/complications ; Diabetes Mellitus, Type 2*/drug therapy ; Renal Insufficiency, Chronic*/complications ; Sodium-Glucose Transporter 2 Inhibitors*; Benzhydryl Compounds/adverse effects ; Glomerular Filtration Rate ; Glucosides ; Humans
- Abstract: Objective: The Dapagliflozin and Prevention of Adverse outcomes in Chronic Kidney Disease (DAPA-CKD) study demonstrated risk reduction for kidney and cardiovascular outcomes with dapagliflozin versus placebo in participants with chronic kidney disease (CKD) with and without diabetes. We compared outcomes according to baseline glycemic status.
Research Design and Methods: We enrolled participants with CKD, estimated glomerular filtration rate (eGFR) 25-75 mL/min/1.73 m 2 , and urinary albumin-to-creatinine ratio 200-5,000 mg/g. The primary composite end point was sustained eGFR decline ≥50%, end-stage kidney disease, or kidney or cardiovascular death.
Results: Of 4,304 participants, 738 had normoglycemia, 660 had prediabetes, and 2,906 had type 2 diabetes. The effect of dapagliflozin on the primary outcome was consistent ( P for interaction = 0.19) in normoglycemia (hazard ratio [HR] 0.62 [95% CI 0.39, 1.01]), prediabetes (HR 0.37 [0.21, 0.66]), and type 2 diabetes (HR 0.64 [0.52, 0.79]). We found no evidence for effect modification on any outcome. Adverse events were similar, with no major hypoglycemia or ketoacidosis in participants with normoglycemia or prediabetes.
Conclusions: Dapagliflozin safely reduced kidney and cardiovascular events independent of baseline glycemic status.
(© 2021 by the American Diabetes Association.) - References: Kidney Int. 2020 Sep;98(3):769-777. (PMID: 32470492)
N Engl J Med. 2020 Oct 8;383(15):1436-1446. (PMID: 32970396)
Circulation. 2021 Jan 26;143(4):337-349. (PMID: 33175585)
Am J Kidney Dis. 2021 Feb;77(2):280-286. (PMID: 32711072)
J Clin Med. 2019 May 31;8(6):. (PMID: 31159350)
Circulation. 2020 Feb 4;141(5):407-410. (PMID: 31707795)
Diabetologia. 2021 Jan;64(1):42-55. (PMID: 33064182)
N Engl J Med. 2019 Nov 21;381(21):1995-2008. (PMID: 31535829) - Molecular Sequence: ClinicalTrials.gov NCT03036150
figshare 10.2337/figshare.14465844 - Accession Number: 0 (Benzhydryl Compounds)
0 (Glucosides)
0 (Sodium-Glucose Transporter 2 Inhibitors)
1ULL0QJ8UC (dapagliflozin) - Publication Date: Date Created: 20210629 Date Completed: 20210930 Latest Revision: 20210930
- Publication Date: 20221213
- Accession Number: PMC8385469
- Accession Number: 10.2337/dc21-0300
- Accession Number: 34183431
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