Polymorphisms in MHC class I molecules influence their interactions with components of the antigen processing and presentation pathway.

Publisher: Blackwell Pub Country of Publication: England NLM ID: 101232337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-313X (Electronic) Linking ISSN: 17443121 NLM ISO Abbreviation: Int J Immunogenet Subsets: MEDLINE

Original Publication: Oxford, UK : Blackwell Pub., c2005-

Antigen Presentation/*genetics ; Antigens/*genetics ; Histocompatibility Antigens Class I/*genetics ; Peptides/*genetics; Antigen Presentation/immunology ; Antigens/immunology ; Histocompatibility Antigens Class I/immunology ; Histocompatibility Antigens Class II/genetics ; Histocompatibility Antigens Class II/immunology ; Humans ; Peptides/immunology ; Polymorphism, Genetic/genetics

MHC class I (MHC-I) molecules undergo an intricate folding process in order to pick up antigenic peptide to present to the immune system. In recent years, the discovery of a new peptide editor for MHC-I has added an extra level of complexity in our understanding of how peptide presentation is regulated. On top of this, the incredible diversity in MHC-I molecules leads to significant variation in the interaction between MHC-I and components of the antigen processing and presentation pathway. Here, we review our current understanding regarding how polymorphisms in human leukocyte antigen class I molecules influence their interactions with key components of the antigen processing and presentation pathway. A deeper understanding of this may offer new insights regarding how apparently subtle variation in MHC-I can have a significant impact on susceptibility to disease.
(© 2021 John Wiley & Sons Ltd.)

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220012/Z/19/Z Wellcome; 219479/Z/19/Z Wellcome

Keywords: antigens; expression; function; immunology; polymorphism

0 (Antigens)
0 (Histocompatibility Antigens Class I)
0 (Histocompatibility Antigens Class II)
0 (Peptides)

Date Created: 20210627 Date Completed: 20211011 Latest Revision: 20211011

20231215

10.1111/iji.12546

34176210