Neutrophil degranulation biomarkers characterize restrictive echocardiographic pattern with diastolic dysfunction in patients with diabetes.

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  • Additional Information
    • Source:
      Publisher: Wiley Country of Publication: England NLM ID: 0245331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2362 (Electronic) Linking ISSN: 00142972 NLM ISO Abbreviation: Eur J Clin Invest Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford : Wiley
      Original Publication: Berlin, New York, Springer-Verlag, on behalf of the European Society for Clinical Investigation.
    • Subject Terms:
      Neutrophil Activation*; Cardiomyopathy, Dilated/*metabolism ; Cardiomyopathy, Restrictive/*metabolism ; Diabetes Mellitus, Type 2/*metabolism ; Diabetic Cardiomyopathies/*metabolism; Aged ; Biomarkers/metabolism ; Cardiomyopathy, Dilated/diagnostic imaging ; Cardiomyopathy, Dilated/etiology ; Cardiomyopathy, Dilated/physiopathology ; Cardiomyopathy, Restrictive/diagnostic imaging ; Cardiomyopathy, Restrictive/etiology ; Cardiomyopathy, Restrictive/physiopathology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/physiopathology ; Diabetic Cardiomyopathies/diagnostic imaging ; Diabetic Cardiomyopathies/etiology ; Diabetic Cardiomyopathies/physiopathology ; Echocardiography ; Female ; Heart Failure, Diastolic/diagnostic imaging ; Heart Failure, Diastolic/etiology ; Heart Failure, Diastolic/metabolism ; Heart Failure, Diastolic/physiopathology ; Heart Failure, Systolic/diagnostic imaging ; Heart Failure, Systolic/etiology ; Heart Failure, Systolic/metabolism ; Heart Failure, Systolic/physiopathology ; Humans ; Male ; Matrix Metalloproteinase 8/metabolism ; Matrix Metalloproteinase 9/metabolism ; Middle Aged ; Peroxidase/metabolism ; Resistin/metabolism ; Tissue Inhibitor of Metalloproteinase-1/metabolism ; Tissue Inhibitor of Metalloproteinase-2/metabolism
    • Abstract:
      Objective: To investigate the potential association between neutrophil degranulation and patterns of myocardial dysfunction in a cohort of patients with type 2 diabetes mellitus (T2DM).
      Background: Two distinct phenotypes of diabetic cardiomyopathy have been described: a restrictive phenotype with diastolic dysfunction (restrictive/DD) and a dilative phenotype with systolic dysfunction (dilative/SD). However, the underlying determinants of these two patterns are not yet recognized.
      Methods: In this single-centre, observational, cross-sectional study, 492 patients were recruited. Ultrasonographic measurements were performed by two experienced sonographers, blinded to the clinical data of the participants. Serum biomarkers of neutrophil degranulation were measured by enzyme-linked immunosorbent sandwich assay (ELISA).
      Results: After adjustment for confounders, resistin, myeloperoxidase, matrix metalloproteinase 8 and matrix metalloproteinase 9/tissue inhibitor of metalloproteinases 1 complex were positively associated with the restrictive/DD pattern compared with the normal pattern. Similarly, MPO was positively associated with the dilative/SD pattern compared with the normal pattern, and resistin was negatively associated with the dilative/SD pattern compared with the restrictive/DD pattern.
      Conclusions: Neutrophil degranulation is associated with the restrictive/DD echocardiographic pattern in patients with T2DM, but not with the normal pattern and dilative/SD patterns. Neutrophils could have a pivotal role in the pathogenesis of myocardial dysfunction, and particularly diastolic dysfunction, in patients with T2DM.
      (© 2021 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.)
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    • Grant Information:
      #2754291 Rete Cardiologica of Italian Ministry of Health; Fondazione Carige to Prof. F
    • Contributed Indexing:
      Keywords: diabetic cardiomyopathy; echocardiography; neutrophils; resistin; type 2 diabetes mellitus
    • Accession Number:
      0 (Biomarkers)
      0 (Resistin)
      0 (Tissue Inhibitor of Metalloproteinase-1)
      127497-59-0 (Tissue Inhibitor of Metalloproteinase-2)
      EC 1.11.1.7 (Peroxidase)
      EC 3.4.24.34 (Matrix Metalloproteinase 8)
      EC 3.4.24.35 (Matrix Metalloproteinase 9)
    • Publication Date:
      Date Created: 20210615 Date Completed: 20220316 Latest Revision: 20220731
    • Publication Date:
      20231215
    • Accession Number:
      PMC9286613
    • Accession Number:
      10.1111/eci.13640
    • Accession Number:
      34129696