[CLINICAL AND IMMUNOLOGICAL FEATURES OF HERPESVIRUS DISEASES ON THE BACKGROUND OF HIV].

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  • Additional Information
    • Source:
      Publisher: Assot︠s︡iat︠s︡ii︠a︡ delovoĭ pressy Gruzii Country of Publication: Georgia (Republic) NLM ID: 101218222 Publication Model: Print Cited Medium: Internet ISSN: 1512-0112 (Print) Linking ISSN: 15120112 NLM ISO Abbreviation: Georgian Med News Subsets: MEDLINE
    • Publication Information:
      Original Publication: Tbilisi : Nʹi︠u︡-Ĭork : Assot︠s︡iat︠s︡ii︠a︡ delovoĭ pressy Gruzii ; International Academy of Science, Education, Industry & Arts
    • Subject Terms:
      HIV Infections*/complications ; HIV Infections*/drug therapy ; Herpesviridae* ; Herpesviridae Infections*/complications ; Herpesviridae Infections*/epidemiology; Antiretroviral Therapy, Highly Active ; CD4-Positive T-Lymphocytes ; Humans
    • Abstract:
      Herpesvirus infections (HI) are the most common HIV-associated diseases. Due to the development of the HIV pandemic, the incidence of HI against the background of HIV infection is steadily increasing, and the implantation of HAART makes certain changes in the course of diseases of this category. The aim of the study was to compare clinical and immunological data in different forms of HI in HIV-positive patients and in patients with normal immune status. From March, 2019 to April 2021, 59 HIV-positive and 60 HIV-negative patients were included in the study. The study used clinical and laboratory methods: ELISA, PCR (HIV RNA, HSV-1, HSV-2, VZV, EBV, CMV, HHV-8), immunological studies (CD3 +, CD4 +, CD8 +, CD4 +/CD8 +, CD20 +). The data were statistically processed using the IBM SPSS Statistics statistical package. The clinical features of herpesvirus skin diseases associated with HIV is closely related to the immune status. The spectrum of clinical manifestations and the incidence of skin and mucous membrane diseases in HIV-infected people are influenced by the severity of immunodeficiency and the systemic use of antiretroviral drugs. The severity of manifestations correlates with the level of CD4 + cells: with a value below 349 cells/μl, an atypical course was observed, and with a value of less than 200 cells/μl, a generalized infectious process.
    • Publication Date:
      Date Created: 20210609 Date Completed: 20210610 Latest Revision: 20210610
    • Publication Date:
      20221213
    • Accession Number:
      34103437