Exercise training decreases intercostal and transversus abdominis muscle blood flows in heart failure rats during submaximal exercise.

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  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 101140022 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1519 (Electronic) Linking ISSN: 15699048 NLM ISO Abbreviation: Respir Physiol Neurobiol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam ; New York : Elsevier Science, c2002-
    • Subject Terms:
      Abdominal Muscles/*physiopathology ; Blood Circulation/*physiology ; Diaphragm/*physiopathology ; Heart Failure/*physiopathology ; Intercostal Muscles/*physiopathology ; Physical Conditioning, Animal/*physiology; Abdominal Muscles/blood supply ; Animals ; Diaphragm/blood supply ; Disease Models, Animal ; Intercostal Muscles/blood supply ; Male ; Random Allocation ; Rats ; Rats, Sprague-Dawley
    • Abstract:
      Diaphragm muscle blood flow (BF) and vascular conductance (VC) are elevated with chronic heart failure (HF) during exercise. Exercise training (ExT) elicits beneficial respiratory muscle and pulmonary system adaptations in HF. We hypothesized that diaphragm BF and VC would be lower in HF rats following ExT than their sedentary counterparts (Sed). Respiratory muscle BFs and mean arterial pressure were measured via radiolabeled microspheres and carotid artery catheter, respectively, during submaximal treadmill exercise (20 m/min, 5 % grade). During exercise, no differences were present between HF + ExT and HF + Sed in diaphragm BFs (201 ± 36 vs. 227 ± 44 mL/min/100 g) or VCs (both, p > 0.05). HF + ExT compared to HF + Sed had lower intercostal BF (27 ± 3 vs. 41 ± 5 mL/min/100 g) and VC (0.21 ± 0.02 vs. 0.31 ± 0.04 mL/min/mmHg/100 g) during exercise (both, p < 0.05). Further, HF + ExT compared to HF + Sed had lower transversus abdominis BF (20 ± 1 vs. 35 ± 6 mL/min/100 g) and VC (0.14 ± 0.02 vs. 0.27 ± 0.05 mL/min/mmHg/100 g) during exercise (both, p < 0.05). These data suggest that exercise training lowers the intercostal and transversus abdominis BF responses in HF rats during submaximal treadmill exercise.
      (Copyright © 2021 Elsevier B.V. All rights reserved.)
    • References:
      J Physiol. 2010 Jul 1;588(Pt 13):2487-501. (PMID: 20457736)
      Exerc Sport Sci Rev. 2006 Oct;34(4):194-201. (PMID: 17031258)
      Physiol Rep. 2020 Jun;8(12):e14484. (PMID: 32562374)
      Circulation. 1992 Jun;85(6):2119-31. (PMID: 1591831)
      J Appl Physiol (1985). 1988 Aug;65(2):964-70. (PMID: 3139623)
      Respir Physiol Neurobiol. 2018 Jan;247:140-145. (PMID: 29037770)
      Can J Cardiol. 2017 Apr;33(4):508-514. (PMID: 28132741)
      Respir Physiol Neurobiol. 2019 May;263:26-30. (PMID: 30825527)
      Am J Physiol Heart Circ Physiol. 2012 Mar 1;302(5):H1050-63. (PMID: 22101528)
      Am J Physiol. 1992 Feb;262(2 Pt 2):H411-9. (PMID: 1539701)
      Respir Physiol Neurobiol. 2020 Oct;281:103518. (PMID: 32777269)
      Eur J Appl Physiol. 2012 Aug;112(8):3061-8. (PMID: 22194005)
      Am J Physiol Heart Circ Physiol. 2015 Nov;309(9):H1419-39. (PMID: 26320036)
      Cardiovasc Res. 2002 Dec;56(3):479-86. (PMID: 12445889)
      Am J Physiol. 1980 Oct;239(4):H443-H449. (PMID: 7425136)
      Exp Physiol. 2019 Jan;104(1):70-80. (PMID: 30298957)
      J Appl Physiol (1985). 2011 Dec;111(6):1664-70. (PMID: 21903877)
      Respir Physiol. 1995 Aug;101(2):171-82. (PMID: 8570919)
      J Appl Physiol (1985). 1997 Oct;83(4):1291-9. (PMID: 9338439)
      J Appl Physiol (1985). 2004 Nov;97(5):1866-73. (PMID: 15220300)
      Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2465-72. (PMID: 18375714)
      Am J Physiol. 1993 Nov;265(5 Pt 2):H1721-6. (PMID: 8238585)
      Eur J Heart Fail. 2014 May;16(5):574-82. (PMID: 24634346)
      Circulation. 1989 Feb;79(2):324-9. (PMID: 2914350)
      Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1755-61. (PMID: 20817826)
      J Appl Physiol (1985). 2017 Apr 1;122(4):918-924. (PMID: 28126910)
      J Appl Physiol (1985). 2012 Jan;112(1):127-34. (PMID: 21979803)
      J Physiol. 1961 Sep;158:1-14. (PMID: 13696595)
      Respir Physiol Neurobiol. 2017 Sep;243:20-26. (PMID: 28495570)
      J Appl Physiol (1985). 2000 Jan;88(1):186-94. (PMID: 10642380)
      Respir Physiol Neurobiol. 2016 Aug;230:54-9. (PMID: 27195511)
      Am Heart J. 2009 Nov;158(5):768.e1-7. (PMID: 19853695)
      Eur Respir J. 2012 Jun;39(6):1449-57. (PMID: 22034652)
      Nitric Oxide. 2018 Apr 1;74:1-9. (PMID: 29288804)
    • Grant Information:
      K12 HD065987 United States HD NICHD NIH HHS; P20 GM103466 United States GM NIGMS NIH HHS; R15 HL108328 United States HL NHLBI NIH HHS; T32 HL007111 United States HL NHLBI NIH HHS
    • Contributed Indexing:
      Keywords: Diaphragm; HFrEF; Respiratory muscle work
    • Publication Date:
      Date Created: 20210606 Date Completed: 20220120 Latest Revision: 20221003
    • Publication Date:
      20221213
    • Accession Number:
      PMC8319098
    • Accession Number:
      10.1016/j.resp.2021.103710
    • Accession Number:
      34091075