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An elegant nano-injection machinery for sabotaging the host: Role of Type III secretion system in virulence of different human and animal pathogenic bacteria.
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- Author(s): Hajra D;Hajra D; Nair AV; Nair AV; Chakravortty D; Chakravortty D
- Source:
Physics of life reviews [Phys Life Rev] 2021 Sep; Vol. 38, pp. 25-54. Date of Electronic Publication: 2021 May 26.- Publication Type:
Journal Article; Review- Language:
English - Source:
- Additional Information
- Source: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101229718 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1457 (Electronic) Linking ISSN: 15710645 NLM ISO Abbreviation: Phys Life Rev Subsets: MEDLINE
- Publication Information: Original Publication: Amsterdam ; Boston : Elsevier, c2004-
- Subject Terms:
- Abstract: Various Gram-negative bacteria possess a specialized membrane-bound protein secretion system known as the Type III secretion system (T3SS), which transports the bacterial effector proteins into the host cytosol thereby helping in bacterial pathogenesis. The T3SS has a special needle-like translocon that can sense the contact with the host cell membrane and translocate effectors. The export apparatus of T3SS recognizes these effector proteins bound to chaperones and translocates them into the host cell. Once in the host cell cytoplasm, these effector proteins result in modulation of the host system and promote bacterial localization and infection. Using molecular biology, bioinformatics, genetic techniques, electron microscopic studies, and mathematical modeling, the structure and function of the T3SS and the corresponding effector proteins in various bacteria have been studied. The strategies used by different human pathogenic bacteria to modulate the host system and thereby enhance their virulence mechanism using T3SS have also been well studied. Here we review the history, evolution, and general structure of the T3SS, highlighting the details of its comparison with the flagellar export machinery. Also, this article provides mechanistic details about the common role of T3SS in subversion and manipulation of host cellular processes. Additionally, this review describes specific T3SS apparatus and the role of their specific effectors in bacterial pathogenesis by considering several human and animal pathogenic bacteria.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2021 Elsevier B.V. All rights reserved.) - Comments: Comment in: Phys Life Rev. 2021 Dec;39:96-98. (PMID: 34364795)
Comment in: Phys Life Rev. 2021 Dec;39:82-84. (PMID: 34452848)
Comment in: Phys Life Rev. 2021 Dec;39:85-87. (PMID: 34452849) - Contributed Indexing: Keywords: Evolution; Injectisome; Nanomachine; Pathogenesis; Type Three secretion system; Virulence effectors
- Accession Number: 0 (Bacterial Proteins)
0 (Type III Secretion Systems) - Publication Date: Date Created: 20210606 Date Completed: 20211210 Latest Revision: 20220318
- Publication Date: 20231215
- Accession Number: 10.1016/j.plrev.2021.05.007
- Accession Number: 34090822
- Source:
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