Lignans from Lepidium meyenii and Their Anti-Inflammatory Activities.

Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004-

Anti-Inflammatory Agents/*chemistry ; Lepidium/*metabolism ; Lignans/*chemistry; Animals ; Anti-Inflammatory Agents/isolation & purification ; Anti-Inflammatory Agents/pharmacology ; Cell Survival/drug effects ; Interleukin-6/metabolism ; Lignans/isolation & purification ; Lignans/pharmacology ; Lipopolysaccharides/pharmacology ; Macrophages/cytology ; Macrophages/drug effects ; Macrophages/metabolism ; Magnetic Resonance Spectroscopy ; Mice ; Molecular Conformation ; Plant Extracts/chemistry ; RAW 264.7 Cells

Meyeniines A-C (1-3), three new lignans, two known neolignans (4-5), and three known lignans (6-8) were isolated from the rhizomes of Lepidium meyenii. Their structures were identified by comprehensive spectroscopic analyses and computational methods. Compound 1 represents a unique lignan featuring an aromatic ring migration. Compounds 2 and 4-6 were analyzed by chiral HPLC column as enantiomers. Biological evaluation revealed that compound 8 could inhibit IL-6 production in lipopolysaccharide (LPS) induced RAW264.7 cells in a dose-dependent manner.
(© 2021 Wiley-VHCA AG, Zurich, Switzerland.)

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2021B1212040015 Guangdong Key Laboratory for Functional Substances in Medicinal Edible Resources and Healthcare Products; 86000000210 SZU Top Ranking Project

Keywords: Lepidium meyenii; anti-inflammatory activity; lignans; meyeniines A-C

0 (Anti-Inflammatory Agents)
0 (Interleukin-6)
0 (Lignans)
0 (Lipopolysaccharides)
0 (Plant Extracts)

Date Created: 20210604 Date Completed: 20211012 Latest Revision: 20211012

20231215

10.1002/cbdv.202100231

34087032