Effects of INSR genetic polymorphism on hippocampal volume and episodic memory in chinese type 2 diabetes.

Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5233 (Electronic) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE

Publication: Berlin : Springer Verlag
Original Publication: Berlin : Springer International, c1991-

Diabetes Mellitus, Type 2*/complications ; Diabetes Mellitus, Type 2*/genetics ; Memory, Episodic*; Antigens, CD ; China ; Hippocampus ; Humans ; Magnetic Resonance Imaging ; Polymorphism, Single Nucleotide ; Receptor, Insulin/genetics

Aims: We aimed to investigate the effect of the type 2 diabetes-specific insulin/IGF signaling genetic variants on the hippocampal volume and their relationships with episodic memory in Chinese patients with type 2 diabetes.
Methods: Analysis of variance was used to evaluate the genotype-by-diagnosis interaction effect on hippocampal volume in Chinese participants (109 patients with type 2 diabetes, 116 healthy controls). Mediation analysis was performed to test whether the hippocampal volume would mediate the association between genotype and episodic memory in patients with type 2 diabetes.
Results: INSR (rs8101064) exhibited a significant genotype-by-diagnosis interaction effect on the bilateral hippocampal volumes (left, P = 0.020; right, P = 0.004, P FDR < 0.05). The T allele carriers exhibited smaller bilateral hippocampal volumes than the CC homozygotes in patients with type 2 diabetes (left, P = 0.004; right, P = 0.002). Mediation analysis revealed the significant mediation effect of the left hippocampal volume on the association between INSR (rs8101064) genetic polymorphism and the short- and long-term memory scores in patients with type 2 diabetes (short-term memory: 95% CI, -2.716, -0.266; long-term memory: 95% CI, -0.823, -0.103).
Conclusions: Hyperglycemia exposure and INSR (rs8101064) genetic polymorphism had an interaction effect on the hippocampal volume, and the T allele of the INSR (rs8101064) may serve as a risk factor for the decreased hippocampal volume in Chinese patients with type 2 diabetes. The left hippocampal volume mediated the effect of INSR (rs8101064) genetic polymorphism on episodic memory in Chinese patients with type 2 diabetes, which provided a biological pathway for understanding how the INSR (rs8101064) genetic polymorphism affects episodic memory in type 2 diabetes.
(© 2021. Springer-Verlag Italia S.r.l., part of Springer Nature.)

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17JCZDJC36300 Natural Science Foundation of Tianjin City

Keywords: Episodic memory; Hippocampus; Insulin receptor; Insulin/Insulin-like growth factor signaling; Type 2 diabetes

0 (Antigens, CD)
EC 2.7.10.1 (INSR protein, human)
EC 2.7.10.1 (Receptor, Insulin)

Date Created: 20210604 Date Completed: 20211125 Latest Revision: 20220531

20231215

10.1007/s00592-021-01750-6

34085146