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Wando Mount Pleasant Library
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Deletional Tolerance Mediated by Extrathymic Aire-Expressing Cells.
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![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Gardner, James M.; DeVoss, Jason J.; Friedman, Rachel S.; Wong, David J.; Tan, Ying X.; Xuyu Zhou; Johannes, Kellsey P.; Su, Maureen A.; Chang, Howard V.; Krummel, Matthew F.; Anderson, Mark S.
- Source:
Science. 8/8/2008, Vol. 321 Issue 5890, p843-847. 4p. 2 Graphs. - Source:
- Additional Information
- Subject Terms:
- Abstract: The prevention of autoimmunity requires the elimination of self-reactive T cells during their development and maturation. The expression of diverse self-antigens by stromal cells in the thymus is essential to this process and depends, in part, on the activity of the autoimmune regulator (Aire) gene. Here we report the identification of extrathymic Aire-expressing cells (eTACs) resident within the secondary lymphoid organs. These stromally derived eTACs express a diverse array of distinct self-antigens and are capable of interacting with and deleting naïve autoreactive T cells. Using two-photon microscopy, we observed stable antigen-specific interactions between eTACs and autoreactive I cells. We propose that such a secondary network of self-antigen-expressing stromal cells may help reinforce immune tolerance by preventing the maturation of autoreactive T cells that escape thymic negative selection. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Science is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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