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[Long-lasting LDL-C lowering: silence at last].
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- Author(s): Achard M;Achard M; Buhayer A; Buhayer A; Dobretz K; Dobretz K; Ehret G; Ehret G; Mach F; Mach F
- Source:
Revue medicale suisse [Rev Med Suisse] 2021 May 26; Vol. 17 (740), pp. 1039-1046.- Publication Type:
Journal Article- Language:
French - Source:
- Additional Information
- Transliterated Title: Une baisse du cholestérol LDL de longue durée : enfin le silence.
- Source: Publisher: Médecine et Hygiène Country of Publication: Switzerland NLM ID: 101219148 Publication Model: Print Cited Medium: Print ISSN: 1660-9379 (Print) Linking ISSN: 16609379 NLM ISO Abbreviation: Rev Med Suisse Subsets: MEDLINE
- Publication Information: Original Publication: Genève : Médecine et Hygiène, 2005-
- Subject Terms:
- Abstract: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is responsible for the degradation of the LDL-receptor. Inclisiran is a new synthetic interfering ribonucleic acid (siRNA) lowers LDL-cholesterol (LDL-C) levels in the blood by using RNA silencing technology to reduce the production of PCSK9. Inclisiran administered subcutaneously at 0 and 3 months, and then every 6 months has been shown to reduce LDL-C by approximately 50 % in patients at high and very-high cardiovascular risk, or with a diagnosis of familial hypercholesterolemia, but also in patients intolerant to statins. New data are expected, in particular with cardiovascular clinical endpoints, as well as safety for use in adolescents.
Competing Interests: Les auteurs n’ont déclaré aucun conflit d’intérêts en relation avec cet article. - Contributed Indexing: Local Abstract: [Publisher, French] La proprotéine convertase subtilisine/kexine de type 9 (PCSK9) est responsable de la dégradation du LDL (Low Density Lipoprotein)-récepteur. L’inclisiran est un nouveau petit ARN interférent synthétique qui baisse les taux de LDL-cholestérol (LDL-C) circulant en utilisant la technologie de silençage ARN pour réduire la production de PCSK9. Administré par voie sous-cutanée à 0 et 3 mois, puis tous les 6 mois, l’inclisiran a démontré une réduction du LDL-C d’environ 50 % chez des patients à haut et très haut risque cardiovasculaire ou avec un diagnostic d’hypercholestérolémie familiale, mais aussi chez des patients intolérants aux statines. De nouvelles données sont attendues, notamment sur les critères de jugement cliniques cardiovasculaires, ainsi que la sécurité d’emploi chez les adolescents.
- Accession Number: 0 (Anticholesteremic Agents)
0 (Cholesterol, LDL)
0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
EC 3.4.21.- (PCSK9 protein, human)
EC 3.4.21.- (Proprotein Convertase 9) - Publication Date: Date Created: 20210527 Date Completed: 20210528 Latest Revision: 20210528
- Publication Date: 20221213
- Accession Number: 34042340
- Transliterated Title:
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