Maternal gestational diabetes and childhood hyperlipidemia.

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  • Additional Information
    • Source:
      Publisher: Blackwell Science Country of Publication: England NLM ID: 8500858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-5491 (Electronic) Linking ISSN: 07423071 NLM ISO Abbreviation: Diabet Med Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford : Blackwell Science
      Original Publication: Chichester [Sussex, England] ; New York : Wiley, [c1984-
    • Subject Terms:
      Body Mass Index*; Cholesterol/*blood ; Diabetes, Gestational/*blood ; Hyperlipidemias/*blood; Adult ; Birth Weight ; Child ; Child, Preschool ; China/epidemiology ; Female ; Follow-Up Studies ; Humans ; Hyperlipidemias/epidemiology ; Hyperlipidemias/etiology ; Incidence ; Male ; Pregnancy ; Retrospective Studies ; Risk Factors
    • Abstract:
      Aims: Aim of this study is to assess dyslipidemia risk between children exposed to maternal gestational diabetes mellitus (GDM) and those not exposed.
      Methods: We recruited 1144 mother-child pairs (572 GDM and 572 non-GDM women matched by their offspring's age and sex). The age of offspring ranged from 3 to 9 years old. We used general linear models to compare mean values of different lipid profiles among children born to mothers with and without GDM. Logistic regression models were used to assess associations of maternal GDM with abnormal lipid profiles in offspring.
      Results: After adjustment for maternal and children's characteristics, children born to mothers with GDM had lower mean values of high-density-lipoprotein (HDL) cholesterol (1.40 ± 0.01 vs. 1.50 ± 0.01; p < 0.001) and higher mean levels of triglycerides/HDL cholesterol ratio (0.37 ± 0.01 vs. 0.35 ± 0.01; p < 0.05) in comparison with their counterparts born to mothers without GDM. Multivariate-adjusted odds ratios among children exposed to mothers with GDM compared with the counterparts were 2.11 (95% confidence interval [CI 1.15-3.88]) for low HDL cholesterol and 1.35 (95% CI 1.00-1.81) for high triglycerides/HDL cholesterol ratio, respectively.
      Conclusions: Maternal GDM was associated with an increased risk of hyperlipidemia in the offspring during early childhood aged from 3 to 9 years old.
      (© 2021 Diabetes UK.)
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    • Grant Information:
      U54 GM104940 United States GM NIGMS NIH HHS; R01 DK100790 United States DK NIDDK NIH HHS
    • Contributed Indexing:
      Keywords: children; gestational diabetes mellitus; lipid profile
    • Accession Number:
      97C5T2UQ7J (Cholesterol)
    • Publication Date:
      Date Created: 20210522 Date Completed: 20220329 Latest Revision: 20221102
    • Publication Date:
      20231215
    • Accession Number:
      PMC8511106
    • Accession Number:
      10.1111/dme.14606
    • Accession Number:
      34021927