Coronary artery disease in East and South Asians: differences observed on cardiac CT.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 9602087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-201X (Electronic) Linking ISSN: 13556037 NLM ISO Abbreviation: Heart Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BMJ Pub. Group, c1996-
    • Subject Terms:
      Coronary Artery Disease*/diagnostic imaging ; Coronary Artery Disease*/epidemiology ; Plaque, Atherosclerotic*; Asian People ; Computed Tomography Angiography/methods ; Constriction, Pathologic ; Coronary Angiography/methods ; Humans ; Predictive Value of Tests ; Tomography, X-Ray Computed
    • Abstract:
      Epidemiological studies have observed East Asians (EAs) are significantly less likely to develop or die from coronary artery disease (CAD) compared with Caucasians. Conversely South Asians (SAs) develop CAD at higher rate and earlier age. Recently, a range of features derived from cardiac CT have been identified which may further characterise ethnic differences in CAD. Emerging data suggest EAs exhibit less coronary calcification and high-risk, non-calcified plaque compared with Caucasians on CT, with no difference in luminal stenosis. In contrast, SAs exhibit similar to higher coronary calcification and luminal stenosis, smaller luminal dimensions and more high-risk, non-calcified plaque than Caucasians. Beyond demonstrating ethnic differences in CAD, cardiac CT may enhance and individualise cardiovascular risk stratification in EAs and SAs. While data thus far in EAs have demonstrated calcium score and CT-derived luminal stenosis may incrementally predict cardiovascular risk beyond traditional risk scores, there remains a paucity of data assessing its use in SAs. Future studies may clarify the prognostic value of cardiac CT in SAs and investigate how this modality may guide preventative therapy and coronary intervention of CAD in EAs and SAs.
      Competing Interests: Competing interests: DD has received software royalties from Cedars-Sinai Medical Center and research support from the National Institute of Health/National Heart, Lung, and Blood Institute (grant 1R01HL148787-01A1). RB has received research support from Amgen and Astella. TF has served on the speakers' bureau for HeartFlow. JL has served as a consultant for Edwards Lifesciences, Circl CVI and HeartFlow; has served on speakers' bureau for Philips; has received research support from GE Healthcare; and owns stock options in Circl CVI and HeartFlow. ARI has received honoraria from Canon Medical, Artrya and Boston Scientific. BK has received honoraria from Abbott and Medtronic and research support from Canon Medical.
      (© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
    • Contributed Indexing:
      Keywords: CT angiography; coronary artery disease; epidemiology; global health; risk factors
    • Publication Date:
      Date Created: 20210514 Date Completed: 20220429 Latest Revision: 20221207
    • Publication Date:
      20231215
    • Accession Number:
      10.1136/heartjnl-2020-318929
    • Accession Number:
      33985989