Confronting molecular rotors and self-quenched dimers as fluorogenic BODIPY systems to probe biotin receptors in cancer cells.

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  • Additional Information
    • Source:
      Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Print Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE
    • Publication Information:
      Original Publication: Cambridge : Royal Society of Chemistry
    • Subject Terms:
      Boron Compounds/*chemistry ; Fluorescent Dyes/*chemistry ; Neoplasms/*diagnostic imaging ; Receptors, Growth Factor/*analysis; Animals ; Boron Compounds/chemical synthesis ; Cell Line ; Fluorescent Dyes/chemical synthesis ; Humans ; Mice ; Molecular Structure ; Neoplasms/chemistry
    • Abstract:
      Probing receptors at the cell surface to monitor their expression level can be performed with fluorogenic dyes. Biotin receptors (BRs) are particularly interesting as they are overexpressed in cancer cells. Herein, to image BRs, we adapted and systematically compared two fluorogenic systems based on BODIPYs: a molecular rotor and a self-quenched dimer that light up in response to high viscosity and low polarity of the membrane, respectively. The fluorogenic dimer proved to be more efficient than the rotor and allowed BRs to be imaged in cancer cells, which can effectively be discriminated from non-cancer cells.
    • Accession Number:
      0 (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene)
      0 (Boron Compounds)
      0 (Fluorescent Dyes)
      0 (Receptors, Growth Factor)
      0 (biotin receptor)
    • Publication Date:
      Date Created: 20210513 Date Completed: 20210803 Latest Revision: 20210803
    • Publication Date:
      20221213
    • Accession Number:
      10.1039/d1cc00108f
    • Accession Number:
      33982709