Prevalence and profile of nocturnal disturbances in Chinese patients with advanced-stage Parkinson's disease: a cross-sectional epidemiology study.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read Online Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100968555 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2377 (Electronic) Linking ISSN: 14712377 NLM ISO Abbreviation: BMC Neurol Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, [2001-
    • Subject Terms:
      Quality of Life*; Parkinson Disease/*complications ; Sleep Wake Disorders/*epidemiology; Aged ; Asian People ; China ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Sleep ; Surveys and Questionnaires
    • Abstract:
      Background: The impact of nocturnal disturbance (ND) in Parkinson's disease on quality of life of patients in Western Countries is increasingly understood. Our study aimed to investigate ND prevalence and its quality of life impact in patients with advanced Parkinson's disease in China.
      Methods: In a multicenter, tertiary-care hospital, outpatient-based, cross-sectional study, patients with advanced Parkinson's disease (Modified Hoehn & Yahr [H&Y] Stage II-IV with ≥3 h awake "off" time/day) from 10 tertiary hospitals throughout China completed the Parkinson's Disease Sleep Scale-2 (PDSS-2) and Parkinson's Disease Questionnaire-39 (PDQ-39). The primary endpoint was the percentage of patients with significant ND (PDSS-2 total score ≥ 15). Additional endpoints were demographic and clinical characteristics, PDSS-2 and PDQ-39 total and subscale scores, correlation between PDSS-2 and PDQ-39, and risk factors for ND and higher PDSS-2 or PDQ-39 scores.
      Results: Of 448 patients analyzed (mean age 63.5 years, 47.3% female), 70.92% (95% confidence interval: 66.71, 75.13) had significant ND. Presence of ND and higher PDSS-2 scores were associated with longer disease duration and higher H&Y stage. Presence of ND was also associated with more awake "off" time/day and female sex. PDQ-39 scores were significantly worse for patients with ND versus those without ND; worse scores were associated with more awake "off" time/day, female sex, and higher H&Y stage. PDSS-2 and PDQ-39 total scores were associated: Pearson correlation coefficient 0.62 (p < 0.001).
      Conclusions: In China, ND was highly prevalent in patients with advanced Parkinson's disease and adversely impacted quality of life. This study highlights the importance of early diagnosis and optimized management of ND in patients with Parkinson's disease in China.
    • References:
      Chin Med J (Engl). 2018 Apr 20;131(8):883-885. (PMID: 29664045)
      Qual Life Res. 1995 Jun;4(3):241-8. (PMID: 7613534)
      J Zhejiang Univ Sci B. 2010 Jul;11(7):531-8. (PMID: 20593519)
      Chin Med J (Engl). 2018 Dec 20;131(24):2976-2985. (PMID: 30539911)
      Front Neurol. 2019 Apr 16;10:340. (PMID: 31040814)
      J Neurol. 2017 Mar;264(3):476-481. (PMID: 28025665)
      Clin Neurol Neurosurg. 2018 Dec;175:124-129. (PMID: 30408646)
      Health Qual Life Outcomes. 2017 Aug 24;15(1):170. (PMID: 28838316)
      Mov Disord. 2015 Oct;30(12):1591-601. (PMID: 26474316)
      J Neural Transm (Vienna). 2014 Feb;121(2):123-34. (PMID: 24057652)
      Neuroepidemiology. 2017;48(1-2):1-8. (PMID: 28161701)
      Lancet. 2015 Oct 10;386(10002):1441. (PMID: 26466037)
      Exp Neurol. 2013 May;243:57-66. (PMID: 23353924)
      Mov Disord. 2002 Sep;17(5):1036-40. (PMID: 12360555)
      J Neurosci Rural Pract. 2018 Jan-Mar;9(1):92-99. (PMID: 29456351)
      J Parkinsons Dis. 2019;9(3):501-515. (PMID: 31282427)
      Parkinsonism Relat Disord. 2017 Nov;44:6-12. (PMID: 28827011)
      Transl Neurodegener. 2016 Jun 30;5:12. (PMID: 27366321)
      Mov Disord. 2011 Jan;26(1):90-9. (PMID: 21322021)
      Neuropsychiatr Dis Treat. 2019 Aug 05;15:2205-2212. (PMID: 31496703)
      Mov Disord. 2010 Dec 15;25(16):2704-16. (PMID: 20931631)
      Mov Disord. 2011 Mar;26(4):644-52. (PMID: 21312275)
      J Clin Neurosci. 2019 Jan;59:254-258. (PMID: 30314921)
      J Neurol Sci. 2008 Aug 15;271(1-2):153-7. (PMID: 18508085)
      Transl Neurodegener. 2019 Jul 31;8:22. (PMID: 31384434)
      Neurology. 2004 Oct 26;63(8 Suppl 3):S8-11. (PMID: 15505143)
      Neurology. 2004 Oct 26;63(8 Suppl 3):S35-8. (PMID: 15505142)
      J Neurol Neurosurg Psychiatry. 2002 Dec;73(6):629-35. (PMID: 12438461)
      Parkinsons Dis. 2015;2015:970534. (PMID: 26539303)
      Mov Disord Clin Pract. 2019 Mar 18;6(4):294-301. (PMID: 31061837)
      NPJ Parkinsons Dis. 2020 Sep 15;6:25. (PMID: 33015354)
      Lancet Neurol. 2018 Nov;17(11):939-953. (PMID: 30287051)
      Mov Disord. 2002 Jul;17(4):775-81. (PMID: 12210875)
      Acta Neurol Scand. 2015 Jun;131(6):426-30. (PMID: 25402773)
      J Neurol Neurosurg Psychiatry. 2004 Apr;75(4):637-9. (PMID: 15026515)
      PLoS One. 2015 Apr 13;10(4):e0123320. (PMID: 25875494)
      BMC Neurol. 2019 Aug 22;19(1):205. (PMID: 31438888)
      Mov Disord. 2010 Aug 15;25(11):1646-51. (PMID: 20629164)
    • Contributed Indexing:
      Keywords: China; Nocturnal disturbances; Parkinson’s disease; Prevalence; Quality of life; Sleep disorders
    • Publication Date:
      Date Created: 20210513 Date Completed: 20210614 Latest Revision: 20221207
    • Publication Date:
      20231215
    • Accession Number:
      PMC8114718
    • Accession Number:
      10.1186/s12883-021-02217-5
    • Accession Number:
      33980158