Three is a crowd: Clinical outcomes of a twice daily versus a thrice daily metronidazole dosing strategy from a multicenter study.

Publisher: Academic Press Country of Publication: England NLM ID: 9505216 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8274 (Electronic) Linking ISSN: 10759964 NLM ISO Abbreviation: Anaerobe Subsets: MEDLINE

Publication: London : Academic Press
Original Publication: London ; San Diego : Academic Press, c1995-

Anti-Bacterial Agents/*administration & dosage ; Bacteremia/*drug therapy ; Metronidazole/*administration & dosage; Aged ; Bacteremia/mortality ; Bacteria, Anaerobic/classification ; Bacteria, Anaerobic/drug effects ; Bacteria, Anaerobic/genetics ; Bacteria, Anaerobic/isolation & purification ; Drug Administration Schedule ; Female ; Humans ; Length of Stay ; Male ; Middle Aged ; Retrospective Studies ; Treatment Outcome

This was a multicenter, retrospective study of patients with anaerobic bacteremia comparing metronidazole 500 mg every 8 h versus 500 mg every 12 h. Of 782 patients reviewed, 85 met inclusion criteria. There was no significant difference in mortality, length of stay, or escalation of therapy between dosing strategies.
Competing Interests: Declaration of competing interest All authors report no conflicts of interest.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)

Keywords: 12 hour; Anaerobic bacteremia; Dose; Metronidazole

0 (Anti-Bacterial Agents)
140QMO216E (Metronidazole)

Date Created: 20210509 Date Completed: 20220210 Latest Revision: 20220210

20221213

10.1016/j.anaerobe.2021.102378

33965559