Adenine nucleotide metabolism by isolated kidney tubules during oxygen deprivation.

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  • Author(s): Weinberg JM;Weinberg JM
  • Source:
    Biochemical medicine and metabolic biology [Biochem Med Metab Biol] 1988 Jun; Vol. 39 (3), pp. 319-29.
  • Publication Type:
    Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Academic Press Country of Publication: United States NLM ID: 8605718 Publication Model: Print Cited Medium: Print ISSN: 0885-4505 (Print) Linking ISSN: 08854505 NLM ISO Abbreviation: Biochem Med Metab Biol Subsets: MEDLINE
    • Publication Information:
      Publication: Orlando Fl : Academic Press
      Original Publication: San Diego : Academic Press, -c1994.
    • Subject Terms:
      Adenine Nucleotides/*metabolism ; Kidney Cortex/*metabolism ; Kidney Tubules, Proximal/*metabolism; Adenosine Diphosphate/metabolism ; Adenosine Monophosphate/metabolism ; Adenosine Triphosphate/metabolism ; Aerobiosis ; Allopurinol/pharmacology ; Anaerobiosis ; Animals ; Hypoxanthine ; Hypoxanthines/pharmacology ; In Vitro Techniques ; Kinetics ; Rabbits ; Xanthine ; Xanthines/pharmacology
    • Abstract:
      Suspensions enriched in isolated rabbit proximal tubules were subjected to varying degrees of oxygen deprivation-induced injury by incubating them under hypoxic conditions at pH 7.4 or pH 6.6 or under high density pelleted conditions and adenine nucleotide degradation was characterized. The major metabolite was hypoxanthine. Its levels increased with the extent of irreversible injury. It was not further degraded or salvaged. Recovery of cell ATP during reoxygenation was predominantly from the remaining cell nucleotides. Allopurinol did not alter the pattern of purine metabolism or the extent of cell injury. These observations provide information on the intrinsic purine metabolic capacity of renal tubule cells during oxygen deprivation which is relevant to understanding both the salvage mechanisms available in these cells as well as the contribution of purine metabolism to the pathogenesis of oxygen deprivation-induced tubule cell injury.
    • Grant Information:
      DK-01337 United States DK NIDDK NIH HHS; DK-34275 United States DK NIDDK NIH HHS
    • Accession Number:
      0 (Adenine Nucleotides)
      0 (Hypoxanthines)
      0 (Xanthines)
      1AVZ07U9S7 (Xanthine)
      2TN51YD919 (Hypoxanthine)
      415SHH325A (Adenosine Monophosphate)
      61D2G4IYVH (Adenosine Diphosphate)
      63CZ7GJN5I (Allopurinol)
      8L70Q75FXE (Adenosine Triphosphate)
    • Publication Date:
      Date Created: 19880601 Date Completed: 19880902 Latest Revision: 20191029
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/0885-4505(88)90092-8
    • Accession Number:
      3395511