Increased Glucose Activity in Subgenual Anterior Cingulate and Hippocampus of High Performing Older Adults, Despite Amyloid Burden.

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  • Additional Information
    • Source:
      Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam ; Washington : IOS Press, c1998-
    • Subject Terms:
      Amyloid beta-Peptides/*metabolism ; Cognitive Aging/*psychology ; Glucose/*metabolism ; Gyrus Cinguli/*metabolism ; Hippocampus/*metabolism; Aged ; Aged, 80 and over ; Female ; Gyrus Cinguli/diagnostic imaging ; Hippocampus/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Male ; Neuropsychological Tests ; Positron-Emission Tomography
    • Abstract:
      Background: Individuals at 80 years of age or above with exceptional memory are considered SuperAgers (SA), an operationalized definition of successful cognitive aging. SA showed increased thickness and altered functional connectivity in the anterior cingulate cortex as a neurobiological signature. However, their metabolic alterations are yet to be uncovered.
      Objective: Herein, a metabolic (FDG-PET), amyloid (PIB-PET), and functional (fMRI) analysis of SA were conducted.
      Methods: Ten SA, ten age-matched older adults (C80), and ten cognitively normal middle-aged (C50) adults underwent cognitive testing and multimodal neuroimaging examinations. Anterior and posterior regions of the cingulate cortex and hippocampal areas were primarily examined, then subregions of anterior cingulate were segregated.
      Results: The SA group showed increased metabolic activity in the left and right subgenual anterior cingulate cortex (sACC, p < 0.005 corrected, bilateral) and bilateral hippocampi (right: p < 0.0005 and left: p < 0.005, both corrected) as compared to that in the C80 group. Amyloid deposition was above threshold in 30% of SA and C80 (p > 0.05). The SA group also presented decreased connectivity between right sACC and posterior cingulate (p < 0.005, corrected) as compared to that of the C80 group.
      Conclusion: These results support the key role of sACC and hippocampus in SA, even in the presence of amyloid deposition. It also suggests that sACC may be used as a potential biomarker in older adults for exceptional memory ability. Further longitudinal studies measuring metabolic biomarkers may help elucidate the interaction between these areas in the cognitive aging process.
    • Contributed Indexing:
      Keywords: Amyloid deposit; FDG; functional fMRI; high-performing older adults; successful cognitive aging
    • Accession Number:
      0 (Amyloid beta-Peptides)
      IY9XDZ35W2 (Glucose)
    • Publication Date:
      Date Created: 20210503 Date Completed: 20210920 Latest Revision: 20210920
    • Publication Date:
      20231215
    • Accession Number:
      10.3233/JAD-210063
    • Accession Number:
      33935091